4-[(5-氨基-1-甲基-1H-吲哚-3-基)甲基]-3-甲氧基-苯甲酸甲酯合成路线 （共 9 条）
反应条件
hydrogen; palladium on activated charcoal in tetrahydrofuran P=2587.7 Torr; 2 h;
参考文献
Matassa; Maduskuie Jr.; Shapiro; Hesp; Snyder; Aharony; Krell; Keith
Journal of Medicinal Chemistry, 1990 , vol. 33, # 6 p. 1781 - 1790
反应条件
palladium in tetrahydrofuran
参考文献
ICI Americas Inc.
Patent: US4859692 A1, 1989 ;
反应条件
palladium in tetrahydrofuran
参考文献
ICI AMERICAS INC.
Patent: EP199543 B1, 1991 ;
反应条件
1: With copper(I) oxide in 1,4-dioxane T=95 - 100°C; Friedel Crafts alkylation; Large scale reaction; 2: With hydrogen in water; ethyl acetate T=25 - 30°C; P=3677.86 - 4413.43 Torr; Large scale reaction;
参考文献
Goverdhan, Gilla; Reddy, Anumula Raghupathi; Sampath, Aalla; Srinivas, Kurella; Himabindu, Vurimidi; Reddy, Ghanta Mahesh
Organic Process Research and Development, 2009 , vol. 13, # 1 p. 67 - 72
反应条件
1: 45 percent / silver(I) oxide / dioxane / 20 h / 60 °C 2: 1.) NaH / 1.) THF, 10 min, 2.) 30 min 3: 98 percent / H2 / 10percent Pd/C / tetrahydrofuran / 2 h / 2587.7 Torr View Scheme
参考文献
Matassa; Maduskuie Jr.; Shapiro; Hesp; Snyder; Aharony; Krell; Keith
Journal of Medicinal Chemistry, 1990 , vol. 33, # 6 p. 1781 - 1790
反应条件
1: 1.) NaH / 1.) THF, 10 min, 2.) 30 min 2: 98 percent / H2 / 10percent Pd/C / tetrahydrofuran / 2 h / 2587.7 Torr View Scheme
参考文献
Matassa; Maduskuie Jr.; Shapiro; Hesp; Snyder; Aharony; Krell; Keith
Journal of Medicinal Chemistry, 1990 , vol. 33, # 6 p. 1781 - 1790
反应条件
1: 45 percent / silver(I) oxide / dioxane / 20 h / 60 °C 2: 1.) NaH / 1.) THF, 10 min, 2.) 30 min 3: 98 percent / H2 / 10percent Pd/C / tetrahydrofuran / 2 h / 2587.7 Torr View Scheme
参考文献
Matassa; Maduskuie Jr.; Shapiro; Hesp; Snyder; Aharony; Krell; Keith
Journal of Medicinal Chemistry, 1990 , vol. 33, # 6 p. 1781 - 1790
反应条件
1: 74 percent / N-methylmorpholine / CH2Cl2 / 2 h 2: 88 percent / LiOH monohydrate / methanol; tetrahydrofuran; H2O / 20 h View Scheme
参考文献
Matassa; Maduskuie Jr.; Shapiro; Hesp; Snyder; Aharony; Krell; Keith
Journal of Medicinal Chemistry, 1990 , vol. 33, # 6 p. 1781 - 1790
反应条件
1: 74 percent / N-methylmorpholine / CH2Cl2 / 2 h 2: 88 percent / LiOH monohydrate / methanol; tetrahydrofuran; H2O / 20 h 3: 69 percent / 4-(dimethylamino)pyridine, 1-<3-(dimethylamino)propyl>-3-ethylcarbodiimide hydrochloride / CH2Cl2 / 18 h View Scheme
参考文献
Matassa; Maduskuie Jr.; Shapiro; Hesp; Snyder; Aharony; Krell; Keith
Journal of Medicinal Chemistry, 1990 , vol. 33, # 6 p. 1781 - 1790
