hydrogen; palladium on activated charcoal in tetrahydrofuran P=2587.7 Torr; 2 h;

palladium in tetrahydrofuran

1: 98 percent / H2 / 10percent Pd/C / tetrahydrofuran / 2 h / 2587.7 Torr 2: 74 percent / N-methylmorpholine / CH2Cl2 / 2 h 3: 88 percent / LiOH monohydrate / methanol; tetrahydrofuran; H2O / 20 h View Scheme

1: 98 percent / H2 / 10percent Pd/C / tetrahydrofuran / 2 h / 2587.7 Torr 2: 74 percent / N-methylmorpholine / CH2Cl2 / 2 h 3: 88 percent / LiOH monohydrate / methanol; tetrahydrofuran; H2O / 20 h 4: 69 percent / 4-(dimethylamino)pyridine, 1-<3-(dimethylamino)propyl>-3-ethylcarbodiimide hydrochloride / CH2Cl2 / 18 h View Scheme

Multi-step reaction with 2 steps 1: 98 percent / H2 / 10percent Pd/C / tetrahydrofuran / 2 h / 2587.7 Torr2: 74 percent / N-methylmorpholine / CH2Cl2 / 2 h