4-(5-环戊酰基氨基-1-甲基吲哚-3-基甲基)-3-甲氧基苯甲酸合成路线 （共 8 条）
反应条件
LiOH*H2O in methanol; water RefluxLarge scale reaction;
参考文献
Goverdhan, Gilla; Reddy, Anumula Raghupathi; Sampath, Aalla; Srinivas, Kurella; Himabindu, Vurimidi; Reddy, Ghanta Mahesh
Organic Process Research and Development, 2009 , vol. 13, # 1 p. 67 - 72
反应条件
1: 45 percent / silver(I) oxide / dioxane / 20 h / 60 °C 2: 1.) NaH / 1.) THF, 10 min, 2.) 30 min 3: 98 percent / H2 / 10percent Pd/C / tetrahydrofuran / 2 h / 2587.7 Torr 4: 74 percent / N-methylmorpholine / CH2Cl2 / 2 h 5: 88 percent / LiOH monohydrate / methanol; tetrahydrofuran; H2O / 20 h View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 33, # 6 p. 1781 - 1790
反应条件
1: 1.) NaH / 1.) THF, 10 min, 2.) 30 min 2: 98 percent / H2 / 10percent Pd/C / tetrahydrofuran / 2 h / 2587.7 Torr 3: 74 percent / N-methylmorpholine / CH2Cl2 / 2 h 4: 88 percent / LiOH monohydrate / methanol; tetrahydrofuran; H2O / 20 h View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 33, # 6 p. 1781 - 1790
反应条件
1: 98 percent / H2 / 10percent Pd/C / tetrahydrofuran / 2 h / 2587.7 Torr 2: 74 percent / N-methylmorpholine / CH2Cl2 / 2 h 3: 88 percent / LiOH monohydrate / methanol; tetrahydrofuran; H2O / 20 h View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 33, # 6 p. 1781 - 1790
反应条件
1: 45 percent / silver(I) oxide / dioxane / 20 h / 60 °C 2: 1.) NaH / 1.) THF, 10 min, 2.) 30 min 3: 98 percent / H2 / 10percent Pd/C / tetrahydrofuran / 2 h / 2587.7 Torr 4: 74 percent / N-methylmorpholine / CH2Cl2 / 2 h 5: 88 percent / LiOH monohydrate / methanol; tetrahydrofuran; H2O / 20 h View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 33, # 6 p. 1781 - 1790
反应条件
1: 74 percent / N-methylmorpholine / CH2Cl2 / 2 h 2: 88 percent / LiOH monohydrate / methanol; tetrahydrofuran; H2O / 20 h View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 33, # 6 p. 1781 - 1790
反应条件
1: 74 percent / N-methylmorpholine / CH2Cl2 / 2 h 2: 88 percent / LiOH monohydrate / methanol; tetrahydrofuran; H2O / 20 h View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 33, # 6 p. 1781 - 1790
反应条件
4-(N,N-dimethlyamino)pyridine; dicyclohexyl-carbodiimide in dichloromethane T=25 - 35°C;
参考文献
Goverdhan, Gilla; Reddy, Anumula Raghupathi; Sampath, Aalla; Srinivas, Kurella; Himabindu, Vurimidi; Reddy, Ghanta Mahesh
Organic Process Research and Development, 2009 , vol. 13, # 1 p. 67 - 72
