1: 1.) NaH / 1.) THF, 10 min, 2.) 30 min 2: 98 percent / H2 / 10percent Pd/C / tetrahydrofuran / 2 h / 2587.7 Torr View Scheme

1: 1.) NaH / 1.) THF, 10 min, 2.) 30 min 2: 98 percent / H2 / 10percent Pd/C / tetrahydrofuran / 2 h / 2587.7 Torr 3: 74 percent / N-methylmorpholine / CH2Cl2 / 2 h 4: 88 percent / LiOH monohydrate / methanol; tetrahydrofuran; H2O / 20 h View Scheme

1: 1.) NaH / 1.) THF, 10 min, 2.) 30 min 2: 98 percent / H2 / 10percent Pd/C / tetrahydrofuran / 2 h / 2587.7 Torr 3: 74 percent / N-methylmorpholine / CH2Cl2 / 2 h 4: 88 percent / LiOH monohydrate / methanol; tetrahydrofuran; H2O / 20 h 5: 69 percent / 4-(dimethylamino)pyridine, 1-<3-(dimethylamino)propyl>-3-ethylcarbodiimide hydrochloride / CH2Cl2 / 18 h View Scheme

Multi-step reaction with 3 steps 1: 1.) NaH / 1.) THF, 10 min, 2.) 30 min2: 98 percent / H2 / 10percent Pd/C / tetrahydrofuran / 2 h / 2587.7 Torr3: 74 percent / N-methylmorpholine / CH2Cl2 / 2 h