6-甲氧基-1-萘满酮合成路线 （共 219 条）
反应条件
1: (i) NaH, (ii) /BRN= 605309/, dioxane 2: aq. HCO2H, Hg(OAc)2 / acetic acid 3: NaH, 1-methyl-pyrrolidin-2-one / toluene View Scheme
参考文献
Juday; Bukwa; Kaiser; Webb
Journal of medicinal chemistry, 1970 , vol. 13, # 2 p. 314 - 317
反应条件
1: 1.) p-toluenesulphonylhydrazide; 2.) butyllithium 2: 6 percent / NH3 / acetonitrile; H2O / 8 h / Irradiation View Scheme
参考文献
Yamashita; Yamashita, Toshiaki; Yasuda; Yasuda, Masahide; Isami; Isami, Toshihiro; Tanabe; Tanabe, Kimiko; Shima; Shima, Kensuke
Tetrahedron, 1994 , vol. 50, # 31 p. 9275 - 9286
反应条件
JONES'-reagent in acetone 3 h; Heating;
参考文献
Journal fuer Praktische Chemie (Leipzig), , vol. 324, # 4 p. 550 - 556
反应条件
1-iso-propyl-4-methylbenzene; palladium on activated charcoal 48 h; Heating;
参考文献
Kumar, Subodh; Saravanan, Srinivasan; Reuben, Peter; Kumar, Atul
Journal of Heterocyclic Chemistry, 2005 , vol. 42, # 7 p. 1345 - 1355
反应条件
hydrogen sulfide in dichloromethane
参考文献
Warner-Lambert Company
Patent: US4767776 A1, 1988 ;
反应条件
CeCl3 in tetrahydrofuran; hydrogenchloride; diethyl ether
参考文献
Pfizer Inc.
Patent: US2004/57992 A1, 2004 ;
反应条件
1.1: AlCl3, aluminium chloride / toluene / 4 h / Reflux 2.1: α-bromo-α,α-dimethylacetamide; sodium hydroxide / N,N-dimethyl acetamide / 5 h / 20 °C 2.2: 1 h / 50 °C 3.1: hydrogenchloride; copper(l) chloride; sodium nitrite / 0 - 20 °C View Scheme
参考文献
Cui, Li-Qian; Dong, Zhi-Lei; Liu, Kai; Zhang, Chi
Organic Letters, 2011 , vol. 13, # 24 p. 6488 - 6491
反应条件
1.1: trichlorophosphate / 0.5 h / 0 °C / Inert atmosphere 1.2: 2 h / 0 - 80 °C 2.1: ethanol; sodium / 1 h / 0 - 80 °C 3.1: sodium hydroxide; methanol / tetrahydrofuran / 2 h / 50 °C 3.2: pH 5 View Scheme
参考文献
BARBOSA, Joseph; CARSON, Kenneth Gordon; GARDYAN, Michael Walter; HEALY, Jason Patrick; HAN, Qiang; MABON, Ross; PABBA, Praveen; TARVER, JR., James; TERRANOVA, Kristen M.; TUNOORI, Ashok; XU, Xiaolian
Patent: US2012/302562 A1, 2012 ;
US 20120302562 A1
反应条件
1: TsOH 2: bis-(2-methoxy-ethyl) ether 3: NaOH / methanol 4: Zn, Cu(OAc)2 / acetic acid View Scheme
参考文献
Journal of the American Chemical Society, , vol. 95, p. 6655 - 6665
反应条件
hydroxylamine hydrochloride
参考文献
Tang, Wenjun; Capacci, Andrew; Sarvestani, Max; Wei, Xudong; Yee, Nathan K.; Senanayake, Chris H.
Journal of Organic Chemistry, 2009 , vol. 74, # 24 p. 9528 - 9530
