6-甲氧基-1-萘满酮合成路线 （共 219 条）
反应条件
potassium carbonate in methanol; water
参考文献
SmithKline Beecham Corporation
Patent: US6117910 A1, 2000 ;
反应条件
hydrogenchloride; AlCl3; ZnI2 in sodium hydroxide; water; ethyl acetate; benzene
参考文献
Abbott Laboratories
Patent: US5128362 A1, 1992 ;
反应条件
toluene-4-sulfonic acid in tetrahydrofuran; hexane; water; N,N-dimethyl-formamide; toluene
参考文献
Abbott Laboratories
Patent: US5248677 A1, 1993 ;
反应条件
1: ZnI2 2: HCl / ethanol View Scheme
参考文献
Ethyl Corporation
Patent: US4785131 A1, 1988 ;
参考文献
Nagata,W. et al.
Journal of the American Chemical Society, 1972 , vol. 94, p. 4654 - 4672
反应条件
diethyl ether; sodium hydride
参考文献
Journal of the American Chemical Society, , vol. 75, p. 4071,4074
反应条件
sodium ethanolate in diethyl ether T=0 - 20°C;
参考文献
Journal of the Iranian Chemical Society, , vol. 10, # 1 p. 43 - 53
反应条件
sodium hydride in diethyl ether
参考文献
Bulletin de la Societe Chimique de France, , p. 1827 - 1833
反应条件
1: With titanium(IV) isopropylate; ammonia in ethanol T=20°C; 6 h; 2: With sodium tetrahydroborate in ethanol T=0 - 20°C; 3.16 h; 3: With hydrogenchloride; sodium hydroxide; ammonia more than 3 stages;
参考文献
PREDIX PHARMACEUTICALS HOLDINGS, INC.
Patent: WO2006/81332 A1, 2006 ;
Location in patent: Page/Page column 94-95 ;
WO 2006/081332 A1
反应条件
1.1: AlCl3, aluminium chloride / toluene / 4 h / Reflux 2.1: α-bromo-α,α-dimethylacetamide; sodium hydroxide / N,N-dimethyl acetamide / 5 h / 20 °C 2.2: 1 h / 50 °C 3.1: hydrogen bromide; copper(I) bromide; sodium nitrite / 0 - 20 °C View Scheme
参考文献
Cui, Li-Qian; Dong, Zhi-Lei; Liu, Kai; Zhang, Chi
Organic Letters, 2011 , vol. 13, # 24 p. 6488 - 6491
