6-甲氧基-1-萘满酮合成路线 （共 219 条）
反应条件
1.1: AlCl3, aluminium chloride / toluene / 4 h / Reflux 2.1: α-bromo-α,α-dimethylacetamide; sodium hydroxide / N,N-dimethyl acetamide / 5 h / 20 °C 2.2: 1 h / 50 °C 3.1: hydrogenchloride; sodium tetrafluoroborate; sodium nitrite View Scheme
参考文献
Cui, Li-Qian; Dong, Zhi-Lei; Liu, Kai; Zhang, Chi
Organic Letters, 2011 , vol. 13, # 24 p. 6488 - 6491
反应条件
1: 1.) BF3*Et2O, 2.) pyridine, POCl3 / 1.) a) 60 deg C, 2 h, b) 90 deg C, 2 h, 2.) heating 2: sulfur, 5percent Pd/C / 2 h / 190 - 200 °C 3: NaCN / dimethylsulfoxide / 12 h / 160 - 170 °C View Scheme
参考文献
Reddy, P. Aravinda; Reddy, A. Babul; Reddy, G. Ramachandra; Reddy, N. Subbarami
Journal of Heterocyclic Chemistry, 2013 , vol. 50, # 6 p. 1451 - 1456
反应条件
sodium hydride; benzene
参考文献
Cowell; Mathieson
Journal of Pharmacy and Pharmacology, 1957 , vol. 9, p. 549,553
反应条件
1: 58 percent / Et2O*BF3, Pb(OAc)4 / benzene / 22 h / Ambient temperature 2: 2 N NaOH / 2 h / Heating View Scheme
参考文献
Synthesis, , # 9 p. 845 - 846
反应条件
1: 84 percent / aq. HBr 2: K2CO3 / dimethylformamide View Scheme
参考文献
Legoabe, Lesetja J.; Petzer, Anel; Petzer, Jacobus P.
Bioorganic and Medicinal Chemistry Letters, 2014 , vol. 24, # 12 p. 2758 - 2763
反应条件
1: CH3ONa / pyridine / 18 h / Ambient temperature 2: hydrazine hydrate / ethanol / 6 h / Heating 3: 80 percent / 48percent aq. HBr View Scheme
参考文献
Parsia, Maria T. Di; Suarez, Cecilia; Vitolo, Maria J.; Marquez, Victor E.; Beyer, Bernardo; et al.
Journal of Medicinal Chemistry, 1981 , vol. 24, # 1 p. 117 - 119
反应条件
1: 70 percent / p-cymene / 10 percent Pd-C / 48 h / Heating 2: 50 percent / triethylamine / CH2Cl2 / 5 h / 20 °C View Scheme
参考文献
Schoepfer, Joseph; Gay, Brigitte; End, Nicole; Muller, Evelyne; Scheffel, Gisela; Caravatti, Giorgio; Furet, Pascal
Bioorganic and Medicinal Chemistry Letters, 2001 , vol. 11, # 9 p. 1201 - 1203
反应条件
1: 98 percent / lithium bromide / diethyl ether; tetrahydrofuran / Ambient temperature 2: sodium, liquid ammonia / ethanol 3: 71 percent / 10percent aq. HCl View Scheme
参考文献
Marshall,J.A.; Conrow,R.E.
Journal of the American Chemical Society, 1983 , vol. 105, p. 5679
参考文献
Marshall, James A.; Conrow, Raymond E.
Journal of the American Chemical Society, 1980 , vol. 102, # 12 p. 4274 - 4275
反应条件
sodium azide in hydrogenchloride; water T=0 - 20°C; Schmidt reaction;
参考文献
Ortega, Raquel; Huebner, Harald; Gmeiner, Peter; Masaguer, Christian F.
Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 9 p. 2670 - 2674
