6-甲氧基-1-萘满酮合成路线 （共 219 条）
反应条件
potassium tert-butylate in tetrahydrofuran T=50°C; 15 h;
参考文献
Journal of the Chemical Society, Perkin Transactions 1, , # 22 p. 3775 - 3778
反应条件
1: p-TSA 2: 49 percent / tri-n-butyltin methoxide, Pd(AcO)2, tri-o-tolylphosphine / toluene / 100 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 39, # 8 p. 1704 - 1719
反应条件
sodium borohydride; hydrogen; palladium-on-barium sulfate; palladium in hydrogenchloride; diethyl ether; ethanol; chloroform; water; acetic acid; toluene
反应条件
tetra-n-butylammonium tribromide in methanol; dichloromethane T=20°C;
参考文献
Voets, Marieke; Antes, Iris; Scherer, Christiane; Mueller-Vieira, Ursula; Biemel, Klaus; Marchais-Oberwinkler, Sandrine; Hartmann, Rolf W.
Journal of Medicinal Chemistry, 2006 , vol. 49, # 7 p. 2222 - 2231
参考文献
Caldwell, Richard D.; GUCKIAN, Kevin M.; KUMARA VEL, Gnanasambandam; LEE, Wen-Cherng; LIN, Edward Yin-Shiang; LlU, Xiaogao; MA, Bin; SCOTT, Daniel M.; SHl, Zhan; THOMAS, Jermaine; TAVERAS, Arthur G.; ZHENG, Guo Zhu
Patent: US2014/100195 A1, 2014 ;
Location in patent: Page/Page column ;
反应条件
hydrogen bromide; dihydrogen peroxide in water T=20°C; 24 h; Irradiation;
参考文献
Podgorsek, Ajda; Stavber, Stojan; Zupan, Marko; Iskra, Jernej
Tetrahedron, 2009 , vol. 65, # 22 p. 4429 - 4439
反应条件
toluene-4-sulfonic acid in methanol 16 h; Ambient temperature;
参考文献
Groen-Piotrowska, E. M.; Groen, M. B.
Recueil des Travaux Chimiques des Pays-Bas, 1993 , vol. 112, # 12 p. 627 - 634
反应条件
lead(IV) acetate; boron trifluoride diethyl etherate in benzene 22 h; Ambient temperature;
参考文献
Nongrum, F.M.; Myrboh, B.
Synthesis, 1987 , # 9 p. 845 - 846
反应条件
1: 92 percent / aluminum chloride / toluene / 0.5 h / Heating
2: 96 percent / imidazole / dimethylformamide
3: lithium aluminum hydride / diethyl ether; tetrahydrofuran / 2 h / -78 - 20 °C
4: Et3N, methanesulfonyl chloride / CH2Cl2 / 24 h / Ambient temperature
5: tetra-n-butylammonium fluoride / tetrahydrofuran; diethyl ether / 0.17 h / Ambient temperature
View Scheme
参考文献
Woo, L. W. Lawrence; Howarth, Nicola M.; Purohit, Atul; Hejaz, Hatem A. M.; Reed, Michael J.; Potter, Barry V. L.
Journal of Medicinal Chemistry, 1998 , vol. 41, # 7 p. 1068 - 1083
反应条件
1: methanol
2: N,N-dimethyl-formamide
View Scheme
参考文献
Caldwell, Richard D.; GUCKIAN, Kevin M.; KUMARA VEL, Gnanasambandam; LEE, Wen-Cherng; LIN, Edward Yin-Shiang; LlU, Xiaogao; MA, Bin; SCOTT, Daniel M.; SHl, Zhan; THOMAS, Jermaine; TAVERAS, Arthur G.; ZHENG, Guo Zhu
Patent: US2014/100195 A1, 2014 ;
