6-甲氧基-1-萘满酮合成路线 （共 219 条）
反应条件
sodium hydride in tetrahydrofuran
2 h; Heating;
参考文献
Zhuang, Yan; Zapp, Josef; Hartmann, Rolf W.
Archiv der Pharmazie, 1997 , vol. 330, # 11 p. 359 - 361
反应条件
diethyl ether; benzene
Erhitzen des Reaktionsprodukts ohne Zusatz;
参考文献
Howell; Taylor
Journal of the Chemical Society, 1958 , p. 1248,1251
反应条件
acetic anhydride
2.) heating; Multistep reaction;
参考文献
Yamashita; Yamashita, Toshiaki; Yasuda; Yasuda, Masahide; Isami; Isami, Toshihiro; Tanabe; Tanabe, Kimiko; Shima; Shima, Kensuke
Tetrahedron, 1994 , vol. 50, # 31 p. 9275 - 9286
反应条件
oxonium
1.) ether, 0 deg C, 2 h; Yield given. Multistep reaction;
参考文献
Kaliappan; Subba Rao
Tetrahedron Letters, 1996 , vol. 37, # 46 p. 8429 - 8430
反应条件
(i) Mg, Et2O, (ii) /BRN= 972739/, (iii) (heating); Multistep reaction;
参考文献
Julia,M.; Labia,R.
Bulletin de la Societe Chimique de France, 1972 , p. 4151 - 4157
反应条件
1: (phenylsulfonyl)methane With n-butyllithium in tetrahydrofuran; hexane
T=-78°C; Metallation; 0.5 h;
2: 6-methoxy-1,2,3,4-tetrahydronaphthalen-1-one With benzoyl chloride in tetrahydrofuran; hexane
T=-78 - 20°C; Addition; acylation; 3 h;
3: With potassium tert-butylate in tetrahydrofuran; hexane
Elimination; aromatization; 3 h; Heating;
参考文献
Orita, Akihiro; Yaruva, Jayamma; Otera, Junzo
Angewandte Chemie - International Edition, 1999 , vol. 38, # 15 p. 2267 - 2270
反应条件
(i), (ii) Pd-C; Multistep reaction;
参考文献
Bey,P.; Ourisson,G.
Bulletin de la Societe Chimique de France, 1968 , p. 2464 - 2468
反应条件
sodium hydroxide in water
5 h; Reflux;
参考文献
Gupta, Richa; Chaudhary, Ram Pal
Phosphorus, Sulfur and Silicon and the Related Elements, 2012 , vol. 187, # 6 p. 735 - 742
反应条件
lithium diisopropyl amide in tetrahydrofuran; hexane
T=-60 - 20°C; 16 h;
参考文献
Dillard, Robert D.; Hahn, Richard A.; McCullough, Doris; Carr, F. Patrick; Rinkema, Lynn E.; et al.
Journal of Medicinal Chemistry, 1991 , vol. 34, # 9 p. 2768 - 2778
反应条件
1: sulfuric acid / water; diethylene glycol dimethyl ether / 110 °C
2: acetic acid; zinc / water / 3 h / 100 °C
3: methanesulfonic acid / 16 h / 20 °C
View Scheme
参考文献
GLAXOSMITHKLINE LLC; CHEUNG, Mui; TANGIRALA, Raghuram, S.
Patent: WO2014/81995 A1, 2014 ;
