6-甲氧基-1-萘满酮合成路线 （共 219 条）
反应条件
4 A molecular sieve; palladium on activated charcoal
1) toluene, 1 h, reflux, 2) toluene, 110 deg C, 2 h; Yield given. Multistep reaction. Yields of byproduct given;
参考文献
Janin; Bisagni
Synthesis, 1993 , # 1 p. 57 - 59
反应条件
4 A molecular sieve; benzylamine; palladium on activated charcoal
1) toluene, 1 h, reflux, 2) toluene, 150 deg C, 4 h; Yield given. Multistep reaction. Yields of byproduct given;
参考文献
Janin; Bisagni
Synthesis, 1993 , # 1 p. 57 - 59
反应条件
4 A molecular sieve; palladium on activated charcoal
multistep reaction; other solvents, other temperature, other substrates; Product distributionMechanism;
参考文献
Janin; Bisagni
Synthesis, 1993 , # 1 p. 57 - 59
反应条件
1: HCl, ZnCl2, AcOH
2: ethanol / Heating
3: Raney-Ni / ethanol / Heating
4: N2H4, KOH / bis-(2-hydroxy-ethyl) ether / Heating
View Scheme
参考文献
Delobelle,J.; Fetizon,M.
Bulletin de la Societe Chimique de France, 1961 , p. 1900 - 1905
反应条件
1: 85 percent / NaH
2: 1.) sodium derivative / 2.) DME
3: 70 percent / 6N hydrochloric acid / acetic acid / 8 h
4: 1.) NaBH4, NaOH, 2.) hydrogen / 2.) 10percent Pd on carbon / 1. water, 2.) acetic acid
View Scheme
参考文献
Marshall,J.A.; Brady,S.F.
Journal of Organic Chemistry, 1970 , vol. 35, # 12 p. 4068 - 4077
反应条件
1.1: tert.-butyl lithium / tetrahydrofuran; pentane / -65 - -20 °C / Inert atmosphere
1.2: 2 h / -35 - 20 °C / Inert atmosphere
2.1: hydrogenchloride / methanol; water / 0.08 h
3.1: sulfuric acid; acetic acid / 0.5 h / 75 °C
View Scheme
参考文献
Gehring, Andrep.; Bracher, Franz
Synthesis (Germany), 2012 , vol. 44, # 15 p. 2441 - 2447
反应条件
potassium tert-butylate; oxygen in tert-butyl alcohol
T=20°C; 4 h;
参考文献
Inagaki, Ryuta; Ninomiya, Masayuki; Tanaka, Kaori; Watanabe, Kunitomo; Koketsu, Mamoru
Chemical and Pharmaceutical Bulletin, 2013 , vol. 61, # 6 p. 670 - 673
反应条件
(i) Br2, CHCl3, Et2O, (ii) /BRN= 605327/, EtOH; Multistep reaction;
参考文献
Bhat, Shridhar; Olaleye, Omonike; Meyer, Kirsten J.; Shi, Wanliang; Zhang, Ying; Liu, Jun O.
Bioorganic and Medicinal Chemistry, 2012 , vol. 20, # 14 p. 4507 - 4513
反应条件
1: 40percent HBr / acetic acid / 24 h / Heating
2: K2CO3 / acetone / 24 h / Heating
View Scheme
参考文献
Pappa; Segall; Pizzorno; Radice; Amoroso; Gutkind
Farmaco, 1994 , vol. 49, # 5 p. 333 - 336
反应条件
1: 99 percent / 48percent aq. HBr / 3 h / Heating
2: 80 percent / pyridine / 18 h / Ambient temperature
3: 74 percent / LiCl, Pd(PPh3)2Cl2, 2,6-di-tert-butyl-4-methylfenol / dimethylformamide / 18 h / 90 °C
View Scheme
参考文献
Almansa; Carceller; Bartroli; Forn
Synthetic Communications, 1993 , vol. 23, # 21 p. 2965 - 2971
