7-喹啉甲酸合成路线

参考文献

Huff, Joel R.; King, Stella W.; Saari, Walfred S.; Springer, J. P.; Martin, Gregory E.; Williams, Michael
Journal of Medicinal Chemistry, 1985 , vol. 28, # 7 p. 945 - 948

1078-30-47-喹啉甲酸

49713-58-84-氯喹啉-7-甲酸+

1150618-22-64-羟基-7-喹啉羧酸

参考文献

WO2012/177893 A2, ;
WO 2012/177893 A2

1078-30-47-喹啉甲酸

49713-58-84-氯喹啉-7-甲酸+

1150618-22-64-羟基-7-喹啉羧酸

参考文献

AMGEN INC.; BISWAS, Kaustav; BROWN, James; CHEN, Jian, J.; GORE, Vijay, Keshav; HARRIED, Scott; HORNE, Daniel, B.; KALLER, Matthew, R.; LIU, Qingyian; MA, Vu, Van; MONENSCHEIN, Holger; NGUYEN, Thomas, T.; YUAN, Chester, Chenguang; ZHONG, Wenge; ST. JEAN, David, J., Jr.
Patent: WO2012/177893 A2, 2012 ;
WO 2012/177893 A2

1078-30-47-喹啉甲酸

178984-69-54-氯喹啉-7-羧酸甲酯

参考文献

AMGEN INC.; BISWAS, Kaustav; BROWN, James; CHEN, Jian, J.; GORE, Vijay, Keshav; HARRIED, Scott; HORNE, Daniel, B.; KALLER, Matthew, R.; LIU, Qingyian; MA, Vu, Van; MONENSCHEIN, Holger; NGUYEN, Thomas, T.; YUAN, Chester, Chenguang; ZHONG, Wenge; ST. JEAN, David, J., Jr.
Patent: WO2012/177893 A2, 2012 ;
WO 2012/177893 A2

67-56-1甲醇+

1078-30-47-喹啉甲酸

51552-68-2喹啉-7-羧酸甲酯

参考文献

AMGEN INC.; BISWAS, Kaustav; BROWN, James; CHEN, Jian, J.; GORE, Vijay, Keshav; HARRIED, Scott; HORNE, Daniel, B.; KALLER, Matthew, R.; LIU, Qingyian; MA, Vu, Van; MONENSCHEIN, Holger; NGUYEN, Thomas, T.; YUAN, Chester, Chenguang; ZHONG, Wenge; ST. JEAN, David, J., Jr.
Patent: WO2012/177893 A2, 2012 ;
Location in patent: Page/Page column 141-142 ;
WO 2012/177893 A2

186581-53-3重氮甲烷+

1078-30-47-喹啉甲酸

51552-68-2喹啉-7-羧酸甲酯

参考文献

Elderfield; Siegel
Journal of the American Chemical Society, 1951 , vol. 73, p. 5622,5627