1.1: lithium triethylborohydride / tetrahydrofuran / -78 - 20 °C / Inert atmosphere 2.1: bromine / hexane / -78 - 20 °C / Inert atmosphere 2.2: 40 °C / Inert atmosphere 3.1: bis-triphenylphosphine-palladium(II) chloride; formic acid; tributyl-amine / N,N-dimethyl-formamide / 12.08 h / 20 - 60 °C / Inert atmosphere View Scheme

N-dodecane; cesium fluoride in N,N-dimethyl-formamide T=100°C; 4 h;

potassium fluoride; 18-crown-6 ether in tetrahydrofuran 60 h; Ambient temperature;