5-碘-1H-吲唑-3-羧酸甲酯合成路线 （共 7 条）
反应条件
1: 5-Iodoisatin With sodium hydroxide; water T=20°C; 0.25 h; 2: With sulfuric acid; sodium nitrite in water T=0 - 10°C; 0.5 h; 3: methanol With hydrogenchloride; sodium hydroxide; sulfuric acid; tin(ll) chloride more than 3 stages;
参考文献
US2009/12123 A1, ;
Page/Page column 8-9 ;
反应条件
1: 5-Iodoisatin With sodium hydroxide in water T=20°C; 0.25 h; 2: With sulfuric acid; sodium nitrite in water T=0 - 10°C; 0.5 h; 3: methanol With hydrogenchloride; sodium hydroxide; sulfuric acid; tin(ll) chloride more than 3 stages;
参考文献
EP1679308 A1, ;
Page/Page column 38-39 ;
EP 1679308 A1
反应条件
iodine; sodium hydrogensulfite in dichloromethane
参考文献
US2003/187026 A1, ;
US 20030187026 A1
反应条件
iodine; bis-[(trifluoroacetoxy)iodo]benzene in dichloromethane T=20°C;
参考文献
Bioorganic and Medicinal Chemistry, , vol. 14, # 20 p. 6832 - 6846
反应条件
sulfuric acid 6 h; Heating;
参考文献
European Journal of Organic Chemistry, , # 29 p. 4909 - 4916
反应条件
1: HCl / Heating 2: 36 percent / iodine; bis(trifluoroacetoxy)iodobenzene / CH2Cl2 / 20 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry, , vol. 14, # 20 p. 6832 - 6846
反应条件
1: With methanol; sodium hydroxide; water in tetrahydrofuran T=75°C; 4 h; 2: With hydrogenchloride in tetrahydrofuran; water pH=1;
参考文献
Ube Industries, Ltd.; SANTEN PHARMACEUTICAL CO., LTD.
Patent: EP1679308 A1, 2006 ;
Location in patent: Page/Page column 39 ;
EP 1679308 A1
