2-[二(2,2,2-三氟乙氧基)磷酰]丙酸乙酯合成路线 （共 7 条）
反应条件
triethylamine in benzene T=0 - 22°C;
参考文献
Hensel, M. J.; Fuchs, P. L.
Synthetic Communications, 1986 , vol. 16, p. 1285 - 1296
反应条件
1: Bis(2,2,2-trifluoroethyl) phosphonate With N,N,N',N',N'',N''-hexamethylphosphoric triamide; sodium hydride in tetrahydrofuran T=20°C; Metallation; 2: 2-bromopropanoic acid ethyl ester in tetrahydrofuran; N,N,N',N',N'',N''-hexamethylphosphoric triamide T=20°C; Michaelis-Becker reaction; 5 h;
参考文献
Ciszewski, Gregory M.; Jackson, John A.
Organic Preparations and Procedures International, 1999 , vol. 31, # 2 p. 240 - 243
反应条件
aluminum oxide; potassium fluoride in acetonitrile Arbuzov reaction; Heating;
参考文献
Journal of Organic Chemistry, , vol. 67, # 15 p. 5437 - 5439
反应条件
1: 98 percent / NaI, aluminum foil / acetonitrile / 1 h / 82 °C 2: 77 percent / PCl5 / 2 h / 80 °C 3: 92 percent / triethylamine / benzene / 0 - 22 °C View Scheme
参考文献
Synthetic Communications, , vol. 16, p. 1285 - 1296
反应条件
1: 77 percent / PCl5 / 2 h / 80 °C 2: 92 percent / triethylamine / benzene / 0 - 22 °C View Scheme
参考文献
Synthetic Communications, , vol. 16, p. 1285 - 1296
反应条件
1: n-BuLi, HMDS / hexane; tetrahydrofuran / 0.5 h / -78 - 0 °C 2: aq. HCl View Scheme
参考文献
Synthetic Communications, , vol. 21, # 22 p. 2391 - 2396
反应条件
18-crown-6 ether; potassium hexamethylsilazane 1.) THF, toluene, -78 deg C, 5 min, 2.) -78 deg C, 45 min; Yield given. Multistep reaction. Yields of byproduct given;
参考文献
Marshall, James A.; Trometer, Joseph D.; Blough, Bruce E.; Crute, Thomas D.
Journal of Organic Chemistry, 1988 , vol. 53, # 18 p. 4274 - 4282
