(5E)-2-疏基-5-(2-萘亚甲基)-1,3-噻唑-4(5H)-酮合成路线 (共 2 条)
反应条件
piperidine in ethanol T=80°C; Knoevenagel condensation; 8 h; Inert atmosphere;
参考文献
Zvarec, Ondrej; Polyak, Steven W.; Tieu, William; Kuan, Kevin; Dai, Huanqin; Pedersen, Daniel Sejer; Morona, Renato; Zhang, Lixin; Booker, Grant W.; Abell, Andrew D.
Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 8 p. 2720 - 2722
反应条件
sodium hydroxide in tetrahydrofuran; acetone
Ambient temperature;
参考文献
Foye; Tovivich
Journal of Pharmaceutical Sciences, 1977 , vol. 66, # 11 p. 1607 - 1611