苯基2-甲基-4-氧代-3,4-二氢-1(2H)-吡啶羧酸酯合成路线 （共 4 条）
参考文献
Comins, Daniel L.; Foley, Michael A.
Tetrahedron Letters, 1988 , vol. 29, # 51 p. 6711 - 6714
反应条件
1: H2 / 5percent Pd/C / ethanol 2: 1.) THF, -23 deg C, 20 min 2.) 10percent HCl, room temperature, 10 min View Scheme
参考文献
Comins, Daniel L.; Brown, Jack D.
Tetrahedron Letters, 1986 , vol. 27, # 38 p. 4549 - 4552
参考文献
Comins, Daniel L.; Stolze, David A.; Thakker, Paresh; McArdle, Cheryl L.
Tetrahedron Letters, 1998 , vol. 39, # 32 p. 5693 - 5696
反应条件
1: 4-methoxy pyridine; phenyl chloroformate in tetrahydrofuran T=-30°C; 0.416667 h; Inert atmosphere; 2: methylmagnesium bromide in tetrahydrofuran T=-45 - -20°C; Inert atmosphere;
参考文献
Pepe, Antonella; Pamment, Michae; Kim, Yeong Sang; Lee, Sunmin; Lee, Min-Jung; Beebe, Kristin; Filikov, Anton; Neckers, Len; Trepel, Jane B.; Malhotra, Sanjay V.
Journal of Medicinal Chemistry, 2013 , vol. 56, # 21 p. 8280 - 8297
