反应条件
1: anhydrous cyanoacetic acid With [2,2']bipyridinyl; n-butyllithium; magnesium sulfate in tetrahydrofuran; hexane
T=-78°C; 0.5 h; Inert atmosphere;
2: 3-methyl-butyryl chloride in tetrahydrofuran; methanol; hexane
T=-78 - 20°C; Inert atmosphere;
3: With hydrogenchloride in tetrahydrofuran; methanol; hexane; water
参考文献
Nowill, Randall W.; Patel, Trisha J.; Beasley, David L.; Alvarez, Jose A.; Jackson III, Elizah; Hizer, Todd J.; Ghiviriga, Ion; Mateer, Scott C.; Feske, Brent D.
Tetrahedron Letters, 2011 , vol. 52, # 19 p. 2440 - 2442
