1: With tert.-butyl lithium in tetrahydrofuran; diethyl ether
T=-78 - 20°C; 18 h;
2: With hydrogenchloride in tetrahydrofuran; diethyl ether; water
1 h;
参考文献
ANACOR PHARMACEUTICALS, INC.
Patent: WO2005/123095 A1, 2005 ;
Location in patent: Page/Page column 47-48 ;