反应条件
1: 87 percent / Et3N / 12 h / 100 °C
2: 89 percent / NH3, MeONa / methanol / 8 h
3: 73 percent / LiAlH4 / tetrahydrofuran; diethyl ether / Heating
4: 75 percent / Et3N / toluene / 6 h / Heating
5: 52 percent / 2 N HCl / 5 h / Heating
6: 1.) LiAlH4, 2.) aq. NaOH / 1.) Et2O, reflux, 3 h, 2.) Et2O, RT, 30 min
View Scheme
参考文献
Giannangeli, Marilena; Cazzolla, Nicola; Luparini, Maria Rita; Magnani, Maurizio; Mabilia, Massimo; Picconi, Giuseppe; Tomaselli, Mauro; Baiocchi, Leandro
Journal of Medicinal Chemistry, 1999 , vol. 42, # 3 p. 336 - 345