1: sodium nitrite; trifluoroacetic acid; sodium azide / water / |Cooling
2: L-proline; sodium carbonate / dimethyl sulfoxide / 75 °C / |Microwave irradiation
3: water; lithium hydroxide hydrate / tetrahydrofuran / 1 h / 20 °C
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参考文献
BRISTOL-MYERS SQUIBB COMPANY; PINTO, Donald J.; CORTE, James R.; GILLIGAN, Paul J.; FANG, Tianan; SMITH II, Leon M.; WANG, Yufeng; YANG, Wu; EWING, William R.
Patent: WO2013/22818 A1, 2013 ;
WO 2013/022818 A1