1: 1-amino-3-methylbenzene With hydrogenchloride; sodium nitrite in water
T=0 - 5°C;
2: malononitrile With sodium acetate in ethanol; water
T=0 - 5°C; pH=3 - 4; 1.5 h;
参考文献
Deeb; Yassin; Ouf; Shehta
Chemistry of Heterocyclic Compounds, 2010 , vol. 46, # 2 p. 212 - 222
in dichloromethane
room temperature, 3 h, reflux, 5 h;
参考文献
Kamigata, Nobumasa; Yamamoto, Kazutoshi; Kawakita, Osamu; Hikita, Kiyoyuki; Matsuyama, Haruo; et al.
Bulletin of the Chemical Society of Japan, 1984 , vol. 57, # 12 p. 3601 - 3602