1: 1-amino-3-methylbenzene With hydrogenchloride; sodium nitrite in water
T=0°C;
2: 2-methyl-3-oxobutanoic acid ethyl ester With sodium acetate in ethanol; water
4 h; Cooling;
参考文献
Matiichuk; Potopnyk; Obushak
Russian Journal of Organic Chemistry, 2008 , vol. 44, # 9 p. 1352 - 1361
Meth-Cohn, Otto; Rhouati, Salah; Tarnowski, Brian; Robinson, Andrew
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1981 , p. 1537 - 1543
1: 97 percent / diethyl ether / 0.08 h / 0 °C
2: 90 percent / phosphoryl chloride / 2 h / 75 °C
View Scheme
参考文献
Meth-Cohn, Otto; Rhouati, Salah; Tarnowski, Brian; Robinson, Andrew
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1981 , p. 1537 - 1543
4-(N,N-dimethlyamino)pyridine; triethylamine in dichloromethane
T=20°C; 5 h; Inert atmosphere;
参考文献
Hwang, Soonho; Choi, Sang Yoon; Lee, Jin Hee; Kim, Shinae; In, Jinkyung; Ha, Sang Keun; Lee, Eunjung; Kim, Tae-Yoon; Kim, Sun Yeou; Choi, Sun; Kim, Sanghee
Bioorganic and Medicinal Chemistry, 2010 , vol. 18, # 15 p. 5602 - 5609
