反应条件
1: 2) BH3-Me2S / 1) THF, r.t., 2 h, 2) THF, reflux, 3 h
2: 26 g / pyridine / CH2Cl2 / 1 h / 0 °C
3: 26.8 g / NBS, AIBN / CCl4 / 3 h / Heating
4: 34 g / toluene / 36 h / Heating
5: 1) t-BuOK / 1) THF, 0 deg C, 30 min, 2) THF, 0 deg C, 4 h
6: H2, NaHCO3 / 10percent Pd/C / methanol / 760 Torr
7: 14.2 g / KOH / ethanol / Heating
8: 83 percent Turnov. / pyridine / CH2Cl2 / 1.) 0 deg C, 2 h, 2.) r.t., 3 h
9: DOWEX-50X8-400R, MeOH / 20 h / 50 °C
10: Et3N / CH2Cl2 / 1 h / 0 °C
11: 10.6 g / LiI / dimethylformamide / 3.5 h / 90 °C
12: 72 percent Turnov. / AgNO2 / diethyl ether / 1.) 0 deg C, 1 d, 2.) r.t., 12 d, in darkness
View Scheme
参考文献
Confalone, Pat N.; Ko, Soo S.
Tetrahedron Letters, 1984 , vol. 25, # 9 p. 947 - 950
