1.1: hydrogenchloride; KIO3; potassium iodide / methanol; water / 0 - 20 °C / Large scale reaction
2.1: pyridine / 10 °C
2.2: 39 - 55 °C / Large scale reaction
3.1: palladium diacetate; triethylamine; tris-(o-tolyl)phosphine
4.1: [Rh(1,5-COD)(S,S-Et-FerroTANE)]BF4; hydrogen / ethyl acetate / 16 h / 60 °C / 3750.38 Torr
5.1: 4-(N,N-dimethlyamino)pyridine / tetrahydrofuran / 16 h / 20 °C
5.2: 5 h / 20 °C
5.3: pH 4
View Scheme
参考文献
Praquin, Celine F. B.; De Koning, Pieter D.; Peach, Philip J.; Howard, Roger M.; Spencer, Sarah L.
Organic Process Research and Development, 2011 , vol. 15, # 5 p. 1124 - 1129
potassium carbonate in acetone
6 h; RefluxInert atmosphereGlovebox; chemoselective reaction;
参考文献
Haibach, Michael C.; Guan, Changjian; Wang, David Y.; Li, Bo; Lease, Nicholas; Steffens, Andrew M.; Krogh-Jespersen, Karsten; Goldman, Alan S.
Journal of the American Chemical Society, 2013 , vol. 135, # 40 p. 15062 - 15070