1-氨基-3,5-二甲苯合成路线 （共 187 条）
反应条件
1: (3,5-dimethylphenyl)-(7-methoxymethyl-[1,4]-dioxano[2,3-g]quinazolin-4-yl)-amine With hydrogenchloride in water
T=0 - 5°C;
2: With sodium tetrafluoroborate; sodium nitrite in water
T=5°C; 0.166667 h;
3: diphenyldimethoxysilane With methanol; palladium diacetate
T=25°C; Hiyama coupling; 6 h;
参考文献
Cheng, Kai; Wang, Chen; Ding, Yiyuan; Song, Qingbao; Qi, Chenze; Zhang, Xian-Man
Journal of Organic Chemistry, 2011 , vol. 76, # 22 p. 9261 - 9268
反应条件
1: 1) NaNO2, 10percent aq. HCl, 2) CH3COONa / 1) 50percent aq. MeOH, 0 deg C, 2) r.t.
2: NH3 / ethanol / 1 h / -78 °C
3: 9 percent / MnO2 / benzene / 4 h / Ambient temperature
View Scheme
参考文献
Bruche, Luca; Garanti, Luisa; Zecchi, Gaetano
Journal of Heterocyclic Chemistry, 1989 , vol. 26, # 26 p. 619 - 624
反应条件
isopentylnitrile
Heating;
参考文献
Bunce, Nigel J.; DeSchutter, Connie T.; Toone, Eric J.
Journal of the Chemical Society, Perkin Transactions 2: Physical Organic Chemistry (1972-1999), 1983 , p. 859 - 862
反应条件
(i) NaNO2, (ii) /BRN= 1788841/; Multistep reaction;
参考文献
Garg,H.G.; Sharma,R.A.
Journal of Medicinal Chemistry, 1970 , vol. 13, p. 991 - 992
反应条件
Yield given. Multistep reaction. Further byproducts given. Yields of byproduct given. Title compound not separated from byproducts;
参考文献
Novrocik, Jan; Novrocikova, Marta; Titz, Milos
Collection of Czechoslovak Chemical Communications, 1980 , vol. 45, # 11 p. 3140 - 3149
反应条件
Yield given. Multistep reaction. Further byproducts given. Yields of byproduct given. Title compound not separated from byproducts;
参考文献
Novrocik, Jan; Novrocikova, Marta; Titz, Milos
Collection of Czechoslovak Chemical Communications, 1980 , vol. 45, # 11 p. 3140 - 3149
反应条件
1: in acetic acid
2: With bromine in acetic acid
cooling; Further stages.;
参考文献
Rodriguez, Gema; Albrecht, Martin; Schoenmaker, Jeroen; Ford, Alan; Lutz, Martin; Spek, Anthony L.; Van Koten, Gerard
Journal of the American Chemical Society, 2002 , vol. 124, # 18 p. 5127 - 5138
反应条件
1.1: n-butyllithium / hexane; tetrahydrofuran / 0.58 h / -78 - -40 °C
1.2: 2.5 h / -78 °C
1.3: 2.5 h / -78 - 0 °C
2.1: dichloromethane / 0 - 20 °C
View Scheme
参考文献
Sung, Moo Je; Coppola, Gary Mark; Yoon, Taeyoung; Gilmore, Thomas A.
Patent: US2011/46133 A1, 2011 ;
反应条件
tert.-butylnitrite; trimethylsilylazide in acetonitrile
T=0 - 20°C;
参考文献
Shi, Feng; Waldo, Jesse P.; Chen, Yu; Larock, Richard C.
Organic Letters, 2008 , vol. 10, # 12 p. 2409 - 2412
反应条件
Yield given. Multistep reaction. Further byproducts given. Yields of byproduct given. Title compound not separated from byproducts;
参考文献
Novrocik, Jan; Novrocikova, Marta; Titz, Milos
Collection of Czechoslovak Chemical Communications, 1980 , vol. 45, # 11 p. 3140 - 3149
