1-氨基-3,5-二甲苯合成路线 （共 187 条）
反应条件
1: 68 percent / NaHCO3 / aq. ethanol / 96 h / Heating
2: 97 percent / triethylamine / hexane / ice-water bath, then room temperature, 1 h
3: 93 percent / 30 percent (CF3CO)2O / trifluoroacetic acid / 72 h / 56 °C
View Scheme
参考文献
Nordlander, J. Eric; Catalane, David B.; Kotian, Kirtivan D.; Stevens, Randall M.; Haky, Jerome E.
Journal of Organic Chemistry, 1981 , vol. 46, p. 778 - 782
反应条件
1: 58 percent / AcOH / 24 h / Heating
2: 95 percent / H2 / Pd/C / ethyl acetate / 3 h
View Scheme
参考文献
Suizu, Mamiko; Muroya, Yohei; Kakuta, Hiroki; Kagechika, Hiroyuki; Tanatani, Aya; Nagasawa, Kazuo; Hashimoto, Yuichi
Chemical and Pharmaceutical Bulletin, 2003 , vol. 51, # 9 p. 1098 - 1102
反应条件
acetic acid
24 h; Heating;
参考文献
Suizu, Mamiko; Muroya, Yohei; Kakuta, Hiroki; Kagechika, Hiroyuki; Tanatani, Aya; Nagasawa, Kazuo; Hashimoto, Yuichi
Chemical and Pharmaceutical Bulletin, 2003 , vol. 51, # 9 p. 1098 - 1102
反应条件
1: AcOH / 24 h / Heating
2: H2 / Pd/C / ethyl acetate / 3 h
View Scheme
参考文献
Suizu, Mamiko; Muroya, Yohei; Kakuta, Hiroki; Kagechika, Hiroyuki; Tanatani, Aya; Nagasawa, Kazuo; Hashimoto, Yuichi
Chemical and Pharmaceutical Bulletin, 2003 , vol. 51, # 9 p. 1098 - 1102
反应条件
1: AcOH / 24 h / Heating
2: 31 percent / Sn; aq. HCl / ethanol / 8 h / 75 °C
View Scheme
参考文献
Suizu, Mamiko; Muroya, Yohei; Kakuta, Hiroki; Kagechika, Hiroyuki; Tanatani, Aya; Nagasawa, Kazuo; Hashimoto, Yuichi
Chemical and Pharmaceutical Bulletin, 2003 , vol. 51, # 9 p. 1098 - 1102
反应条件
1: AcOH / 24 h / Heating
2: 38 percent / Sn; aq. HCl / ethanol / 8 h / 75 °C
View Scheme
参考文献
Suizu, Mamiko; Muroya, Yohei; Kakuta, Hiroki; Kagechika, Hiroyuki; Tanatani, Aya; Nagasawa, Kazuo; Hashimoto, Yuichi
Chemical and Pharmaceutical Bulletin, 2003 , vol. 51, # 9 p. 1098 - 1102
反应条件
1: AcOH / 24 h / Heating
2: 67 percent / borane / tetrahydrofuran / 16 h / Heating
3: H2 / Pd/C / ethyl acetate / 3 h
View Scheme
参考文献
Suizu, Mamiko; Muroya, Yohei; Kakuta, Hiroki; Kagechika, Hiroyuki; Tanatani, Aya; Nagasawa, Kazuo; Hashimoto, Yuichi
Chemical and Pharmaceutical Bulletin, 2003 , vol. 51, # 9 p. 1098 - 1102
参考文献
Helmholz, Falko; Schroeder, Rita; Langer, Peter
Zeitschrift fur Naturforschung - Section B Journal of Chemical Sciences, 2005 , vol. 60, # 11 p. 1192 - 1196
参考文献
Helmholz, Falko; Schroeder, Rita; Langer, Peter
Zeitschrift fur Naturforschung - Section B Journal of Chemical Sciences, 2005 , vol. 60, # 11 p. 1192 - 1196
反应条件
toluene-4-sulfonic acid in diphenylether; dichloromethane; pentane
参考文献
Bayer Aktiengesellschaft
Patent: US5756517 A1, 1998 ;
