1-氨基-3,5-二甲苯合成路线 （共 187 条）
参考文献
Backeberg; Friedmann
Journal of the Chemical Society, 1938 , p. 972,976
反应条件
sodium tungstate; tetrabutylammomium bromide; dihydrogen peroxide in dichloromethane; water; pentane
T=20°C; 18 h;
参考文献
GEORGETOWN UNIVERSITY
Patent: WO2005/7659 A2, 2005 ;
Location in patent: Page/Page column 50 ;
反应条件
dihydrogen peroxide; diphenyl diselenide in chloroform
T=20°C; 8 h; Title compound not separated from byproducts.;
参考文献
Zhao, Dongbo; Johansson, Mikael; Baeckvall, Jan-E.
European Journal of Organic Chemistry, 2007 , # 26 p. 4431 - 4436
反应条件
1: butyllithium / tetrahydrofuran; hexane / 1 h / 25 °C
2: 81.8 g / hydrochloric acid / 5 h / 50 °C
View Scheme
参考文献
Ondi, Levente; Volle, Jean-Noel; Schlosser, Manfred
Tetrahedron, 2005 , vol. 61, # 3 p. 717 - 725
反应条件
1: butyllithium / tetrahydrofuran; hexane / 1 h / 25 °C
2: 81.8 g / hydrochloric acid / 5 h / 50 °C
3: 82 percent / phosphoric tribromide / various solvent(s) / 2 h / Heating
View Scheme
参考文献
Ondi, Levente; Volle, Jean-Noel; Schlosser, Manfred
Tetrahedron, 2005 , vol. 61, # 3 p. 717 - 725
反应条件
1.1: butyllithium / tetrahydrofuran; hexane / 1 h / 25 °C
2.1: 81.8 g / hydrochloric acid / 5 h / 50 °C
3.1: 82 percent / phosphoric tribromide / various solvent(s) / 2 h / Heating
4.1: diisopropylamine; butyllithium / tetrahydrofuran; hexane / 2 h / -75 °C
4.2: 82 percent / tetrahydrofuran; hexane
View Scheme
参考文献
Ondi, Levente; Volle, Jean-Noel; Schlosser, Manfred
Tetrahedron, 2005 , vol. 61, # 3 p. 717 - 725
反应条件
(i) Ac2O, (ii) /BRN= 605303/, AlCl3, (iii) aq. HCl; Multistep reaction;
参考文献
Itier,J.; Casadevall,A.
Bulletin de la Societe Chimique de France, 1969 , p. 2342 - 2355
反应条件
1: 86 percent / NaOAc / propan-2-ol / 30 h / Heating
2: 55 percent / AlCl3, 3,5-xylidine / 20 h / 180 °C
3: 1.) 6N H2SO4, NaNO2; 2.) NaN3 / 1.) 0-5 deg C, 15 min, dioxane, water; 2.) 40-50 deg C, water
View Scheme
参考文献
Murata,S.; Sugawara,T.; Iwamura,H.
Journal of the American Chemical Society, 1985 , vol. 107, p. 6317
反应条件
1: 62 percent / pyridine / 20 °C
2: 69 percent / H2 / Pd/C / ethanol / 750.06 Torr
View Scheme
参考文献
Yu, Shenghui; Zhang, Linna; Yan, Shifeng; Wang, Peng; Sanchez, Tino; Christ, Frauke; Debyser, Zeger; Neamati, Nouri; Zhao, Guisen
Journal of Enzyme Inhibition and Medicinal Chemistry, 2012 , vol. 27, # 5 p. 628 - 640
反应条件
1: 66 percent
View Scheme
参考文献
Halladay, Peter K.; Cowden, William B.
Australian Journal of Chemistry, 1990 , vol. 43, # 8 p. 1449 - 1454
