1-氨基-3,5-二甲苯合成路线 （共 187 条）
反应条件
1: (i) (diazotization), aq. HBr, (ii) Cu 2: (i) Mg, (ii) /BRN= 1209228/ 3: SOCl2 4: aq. ethanol View Scheme
参考文献
van Zanten,B.; Nauta,W.
Recueil des Travaux Chimiques des Pays-Bas, 1960 , vol. 79, p. 1211 - 1222
反应条件
1: With acetic anhydride; triethylamine in chloroform T=20°C; 4 h; 2: With N-bromosuccinmide in acetonitrile T=20°C; 12 h; 3: With hydrogenchloride; water in ethanol 6 h; Heating;
参考文献
Toyota, Kozo; Kawasaki, Subaru; Yoshifuji, Masaaki
Journal of Organic Chemistry, 2004 , vol. 69, # 15 p. 5065 - 5070
反应条件
sodium hydroxide in dichloromethane T=0 - 20°C; 25 h;
参考文献
Li, Zheng-Yi; Ma, Hong-Zhao; Han, Chen; Xi, Hai-Tao; Meng, Qi; Chen, Xin; Sun, Xiao-Qiang
Synthesis (Germany), 2013 , vol. 45, # 12 art. no. SS-2013-F0228-OP, p. 1667 - 1674
反应条件
1: ethyl acetate / 1 h / 26 °C 2: iron sulphate heptahydrate; triethylamine / ethyl acetate / 5 h View Scheme
参考文献
Li, Zheng-Yi; Ma, Hong-Zhao; Han, Chen; Xi, Hai-Tao; Meng, Qi; Chen, Xin; Sun, Xiao-Qiang
Synthesis (Germany), 2013 , vol. 45, # 12 art. no. SS-2013-F0228-OP, p. 1667 - 1674
反应条件
in chloroform T=20°C; 2 h;
参考文献
Yan, Shunqi; Appleby, Todd; Gunic, Esmir; Shim, Jae Hoon; Tasu, Tania; Kim, Hongwoo; Rong, Frank; Chen, Huaming; Hamatake, Robert; Wu, Jim Z.; Hong, Zhi; Yao, Nanhua
Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 1 p. 28 - 33
反应条件
sodium carbonate in toluene T=20°C; 1.5 h;
参考文献
Costa, Jorge C.S.; Neves, Josiane S.; de Souza, Marcus V.N.; Siqueira, Rodrigo A.; Romeiro, Nelilma C.; Boechat, Nubia; Silva, Patricia M.R.e; Martins, Marco A.
Bioorganic and Medicinal Chemistry Letters, 2008 , vol. 18, # 3 p. 1162 - 1166
反应条件
sodium hydrogencarbonate in acetic acid; ethyl acetate
参考文献
Kyoto Pharmaceutical Industries, Ltd.
Patent: US6063806 A1, 2000 ;
反应条件
1: ueber die Diazonium-Verbindung 2: diethyl ether / anschliessend Erwaermen mit verd. wss. Schwefelsaeure View Scheme
参考文献
Birch et al.
Journal of the American Chemical Society, 1949 , vol. 71, p. 1362,1366
参考文献
Tedjamulia, Marvin L.; Tominaga, Yoshinori; Castle, Raymond N.
Journal of Heterocyclic Chemistry, 1983 , vol. 20, p. 1485 - 1495
反应条件
methanesulfonic acid; sodium chloride; ammonia; sodium nitrite; Copper(I)chloride in hydrogenchloride; water; acetic acid
参考文献
Merrell Dow Pharmaceuticals Inc.
Patent: US4563465 A1, 1986 ;
