反应条件
1.1: pyridine
2.1: sodium hydride; water / N,N-dimethyl-formamide / 0 °C
3.1: potassium carbonate / N,N-dimethyl-formamide / -20 °C
4.1: trifluoroacetic anhydride / dichloromethane / 0.17 h / 0 °C
4.2: 20 °C
5.1: sodium methylate / methanol; dichloromethane / 0.5 h
6.1: potassium carbonate; tetrabutylammomium bromide / chloroform; water / 1 h / 50 °C
6.2: 24 h / 50 °C
7.1: 10 Pd/C; acetic acid; hydrogen / ethyl acetate / 4 h / 760.05 Torr
8.1: sodium methylate / methanol; dichloromethane / 0.5 h
View Scheme
参考文献
Liu, Qingchao; Guo, Tiantian; Li, Wenhong; Li, Dong; Feng, Zili
Archiv der Pharmazie, 2012 , vol. 345, # 10 p. 771 - 783
