4,6-二甲基-2-羟基嘧啶合成路线 （共 34 条）
反应条件
in para-xylene T=140°C; phosphorylation; 13 h; Product distribution; Further Variations:SolventsTemperaturesReaction partnersreaction time;
参考文献
Russian Journal of General Chemistry, , vol. 69, # 9 p. 1386 - 1388
反应条件
in para-xylene T=140°C; phosphorylation; 13 h; Product distribution; Further Variations:SolventsTemperaturesReaction partnersreaction time;
参考文献
Russian Journal of General Chemistry, , vol. 69, # 9 p. 1386 - 1388
反应条件
in para-xylene T=140°C; phosphorylation; 13 h; Product distribution; Further Variations:SolventsTemperaturesReaction partnersreaction time;
参考文献
Russian Journal of General Chemistry, , vol. 69, # 9 p. 1386 - 1388
参考文献
Biochemical Journal, , vol. 48, p. 394,395
参考文献
Monatshefte fuer Chemie, , vol. 87, p. 526,531
反应条件
1: With sulfuric acid; nitric acid T=0 - 20°C; 5 h; 2: With sodium hydroxide in water pH=~ 4; Cooling with ice;
参考文献
H. LUNDBECK A/S; ESKILDSEN, Jørgen; WENZEL TORNØE, Christian
Patent: WO2013/4617 A1, 2013 ;
Location in patent: Page/Page column 30 ;
WO 2013/004617 A1
反应条件
1.1: nitric acid; sulfuric acid / 5 h / 0 - 20 °C 1.2: pH ~ 4 / Cooling with ice 2.1: trichlorophosphate / 5 h / Reflux 3.1: hydrogen / palladium 10 on activated carbon / ethanol / 5 h / 20 °C View Scheme
参考文献
H. LUNDBECK A/S; ESKILDSEN, Jørgen; WENZEL TORNØE, Christian
Patent: WO2013/4617 A1, 2013 ;
WO 2013/004617 A1
反应条件
trichlorophosphate 1 h; Heating / reflux;
参考文献
TORAY INDUSTRIES, INC.
Patent: EP1840121 A1, 2007 ;
反应条件
in diethyl ether; trichlorophosphate
参考文献
Dupont Pharmaceuticals Company
Patent: US6107301 A1, 2000 ;
US 6107301 A
反应条件
23 h; Heating / reflux;
参考文献
DuPont Pharmaceuticals Company
Patent: US6342503 B1, 2002 ;
Location in patent: Example 1 ;
US 6342503 B1
