反应条件
1: 72 percent / Bu3P; 1,1'-(azodicarbonyl)dipiperidine / CH2Cl2 / 24 h / 20 °C 2: 68 percent / DIPEA / dimethylformamide / 12 h / 20 °C 3: 99 percent / HCl / dioxane / 6 h / 20 °C 4: 56 percent / EDCI; DMAP / tetrahydrofuran; dimethylformamide / 16 h / 20 °C 5: 99 percent / BH3 / tetrahydrofuran / 16 h / 20 °C View Scheme
参考文献
Wendt, Michael D.; Shen, Wang; Kunzer, Aaron; McClellan, William J.; Bruncko, Milan; Oost, Thorsten K.; Ding, Hong; Joseph, Mary K.; Zhang, Haichao; Nimmer, Paul M.; Ng, Shi-Chung; Shoemaker, Alexander R.; Petros, Andrew M.; Oleksijew, Anatol; Marsh, Kennan; Bauch, Joy; Oltersdorf, Tilman; Belli, Barbara A.; Martineau, Darlene; Fesik, Stephen W.; Rosenberg, Saul H.; Elmore, Steven W.
Journal of Medicinal Chemistry, 2006 , vol. 49, # 3 p. 1165 - 1181