4,5,6,7-四氢噻吩[3,2-C]吡啶-2-甲酸乙酯合成路线 (共 2 条)
反应条件
1: With trifluoroacetic acid in dichloromethane T=0 - 20°C; 1 h; 2: With sodium hydrogencarbonate in dichloromethane; water
参考文献
Blackburn, Christopher; Barrett, Cynthia; Chin, Janice; Garcia, Kris; Gigstad, Kenneth; Gould, Alexandra; Gutierrez, Juan; Harrison, Sean; Hoar, Kara; Lynch, Chrissie; Rowland, R. Scott; Tsu, Chris; Ringeling, John; Xu, He
Journal of Medicinal Chemistry, 2013 , vol. 56, # 18 p. 7201 - 7211
反应条件
1: triethylamine / dichloromethane / 2 h / Reflux 2: trifluoroacetic acid / dichloromethane / 3 h / 0 - 5 °C View Scheme
参考文献
WO2012/117421 A1, ;
WO 2012/117421 A1