2-(4-甲氧基苯基)吡嗪合成路线 （共 15 条）
反应条件
ammonium formate; palladium on activated charcoal in methanol T=20°C;
参考文献
Leclerc, Jean-Philippe; Fagnou, Keith
Angewandte Chemie - International Edition, 2006 , vol. 45, # 46 p. 7781 - 7786
反应条件
palladium diacetate; potassium carbonate; triphenylphosphine in ethylene glycol dimethyl ether T=100°C; Suzuki coupling; 5 h;
参考文献
Nakamura, Toshio; Sato, Masakazu; Kakinuma, Hiroyuki; Miyata, Noriyuki; Taniguchi, Kazuo; Bando, Kagumi; Koda, Ayumi; Kameo, Kazuya
Journal of Medicinal Chemistry, 2003 , vol. 46, # 25 p. 5416 - 5427
反应条件
copper(l) iodide; cesium fluoride in N,N-dimethyl-formamide T=120°C; Suzuki-Miyaura Coupling; 60 h; GloveboxInert atmosphere;
参考文献
Gurung, Santosh K.; Thapa, Surendra; Kafle, Arjun; Dickie, Diane A.; Giri, Ramesh
Organic Letters, 2014 , vol. 16, # 4 p. 1264 - 1267
反应条件
potassium tert-butylate T=80°C; 0.5 h; Inert atmosphereMicrowave irradiationDarkness;
参考文献
Yanagisawa, Shuichi; Ueda, Kirika; Taniguchi, Tadashi; Itami, Kenichiro
Organic Letters, 2008 , vol. 10, # 20 p. 4673 - 4676
反应条件
iron (III) acetylacetonate in tetrahydrofuran T=-30°C; 0.166667 h;
参考文献
Boully, Ludovic; Darabantu, Mircea; Turck, Alain; Ple, Nelly
Journal of Heterocyclic Chemistry, 2005 , vol. 42, # 7 p. 1423 - 1428
反应条件
tricyclohexylphosphine-Au(I); potassium tert-butylate T=100°C; 12 h; Inert atmosphere;
参考文献
Li, Ming; Hua, Ruimao
Tetrahedron Letters, 2009 , vol. 50, # 13 p. 1478 - 1481
反应条件
NiCl2(PCy3)2 in benzene T=45°C; 22 h;
参考文献
Hirner, Joshua J.; Blum, Suzanne A.
Organometallics, 2011 , vol. 30, # 6 p. 1299 - 1302
反应条件
dipotassium peroxodisulfate; Fe(acetylacetonate)2; tetrabutylammomium bromide; trifluoroacetic acid in dichloromethane; water T=20°C; 12 h;
参考文献
Singh, Parvinder Pal; Aithagani, Sravan Kumar; Yadav, Mahipal; Singh, Varun Pratap; Vishwakarma, Ram A.
Journal of Organic Chemistry, 2013 , vol. 78, # 6 p. 2639 - 2648
反应条件
chromium dichloride in tetrahydrofuran T=25°C; 0.5 h; Inert atmosphere;
参考文献
Steib, Andreas K.; Kuzmina, Olesya M.; Fernandez, Sarah; Flubacher, Dietmar; Knochel, Paul
Journal of the American Chemical Society, 2013 , vol. 135, # 41 p. 15346 - 15349
反应条件
1: 71 percent / aq. KOH; [Bu4N]Br / tetrahydrofuran 2: 13 percent / 50 °C View Scheme
参考文献
Huh, Dal Ho; Ryu, Hoejin; Kim, Young Gyu
Tetrahedron, 2004 , vol. 60, # 44 p. 9857 - 9862
