反应条件
Multi-step reaction with 8 steps 1: 81 percent / HCl / Ambient temperature2: 91 percent / conc aq. NH4OH / Ambient temperature3: 75 percent / 5percent Pd/C / xylene / 4 h / Heating4: 77 percent / POCl3 / toluene / Heating5: 94 percent / Br2 / tetrahydrofuran / 1 h6: 2.) NaBH4 / 1.) THF, r.t., 1 h, 2.) THF, MeOH, 0 deg C, 0.5 h7: 50 percent / 70percent HClO4 / tetrahydrofuran; H2O / 3 h / Ambient temperature8: 62 percent / borane-trimethylamine / acetic acid; tetrahydrofuran / 1 h / 0 °C
参考文献
Rinehart,K.B.; Kobayashi,J.; Harbour,G.C. Journal of the American Chemical Society, 1987 , vol. 109, p. 3378