1-(2-(4-溴苯氧基)乙基)吡咯烷合成路线 （共 17 条）
反应条件
sodium ethanolate in ethanol T=78°C; 60 h; Inert atmosphere; Reagent/catalyst;
参考文献
Ace, Karl W.; Armitage, Mark A.; Bellingham, Richard K.; Blackler, Paul D.; Ennis, David S.; Hussain, Nigel; Lathbury, David C.; Morgan, David O.; O'Connor, Noah; Oakes, Graham H.; Passey, Stephen C.; Powling, Laurence C.
Organic Process Research and Development, 2001 , vol. 5, # 5 p. 479 - 490
反应条件
in ethanol 18 h; RefluxInert atmosphere;
参考文献
Ace, Karl W.; Armitage, Mark A.; Bellingham, Richard K.; Blackler, Paul D.; Ennis, David S.; Hussain, Nigel; Lathbury, David C.; Morgan, David O.; O'Connor, Noah; Oakes, Graham H.; Passey, Stephen C.; Powling, Laurence C.
Organic Process Research and Development, 2001 , vol. 5, # 5 p. 479 - 490
反应条件
1: thionyl chloride; pyridine / toluene / 2 h / 20 °C / |Reflux; |Dean-Stark 2: ethanol / 18 h / |Reflux; |Inert atmosphere View Scheme
参考文献
Organic Process Research and Development, , vol. 5, # 5 p. 479 - 490
反应条件
dicyclohexyl(2',4',6'-triisopropyl-5-methoxy-3,4,6-trimethyl-[1,1'-biphenyl]-2-yl)phosphine; C50H70NO4PPdS; C50H70NO4PPdS; dicyclohexyl(2',4',6'-triisopropyl-4-methoxy-3,5,6-trimethyl-[1,1'-biphenyl]-2-yl)phosphine; ammonia; sodium t-butanolate in 1,4-dioxane T=80°C; 24 h; Inert atmosphere;
参考文献
Cheung, Chi Wai; Surry, David S.; Buchwald, Stephen L.
Organic Letters, 2013 , vol. 15, # 14 p. 3734 - 3737
反应条件
1: 1-[2-(4-bromo-phenoxy)-ethyl]-pyrrolidine With n-butyllithium; cerium(III) chloride in tetrahydrofuran; hexane T=-78°C; 4 h; 2: (6-methoxy-2-phenyl-3,4-dihydronaphthalene-1(2H)-one) in tetrahydrofuran; hexane T=20°C; 16 h;
参考文献
LEK PHARMACEUTICALS D.D.; GAZIC SMILOVIC, Ivana; SEECHURN, Carin; COLACOT, Thomas J.
Patent: WO2012/159981 A2, 2012 ;
Location in patent: Page/Page column 20-21 ;
反应条件
CeCl3 in tetrahydrofuran; hydrogenchloride; diethyl ether
参考文献
Pfizer Inc.
Patent: US2004/57992 A1, 2004 ;
反应条件
magnesium in tetrahydrofuran
参考文献
Eli Lilly and Company
Patent: US6025382 A1, 2000 ;
反应条件
1: 1-[2-(4-bromo-phenoxy)-ethyl]-pyrrolidine With tert.-butyl lithium in tetrahydrofuran T=-78°C; 1.5 h; Cooling with acetone-dry ice; 2: tri-isopropoxy-borane in tetrahydrofuran T=20°C; 15 h; 3: With hydrogenchloride in tetrahydrofuran T=20°C; 2 h;
参考文献
WO2006/4658 A2, ;
Page/Page column 52-53 ;
WO 2006/004658 A2
反应条件
n-butyllithium; triethylamine in tetrahydrofuran; methanol
参考文献
US2002/10183 A1, ;
US 20020010183 A1
反应条件
n-butyllithium; CeCl3 in tetrahydrofuran; diethyl ether
参考文献
Pfizer Inc
Patent: US2005/70512 A1, 2005 ;
Location in patent: Page/Page column 22 ;
