lithium aluminium tetrahydride in tetrahydrofuran T=25°C; 0.666667 h;

1.1: Mg / diethyl ether 1.2: 100 percent / diethyl ether / 0.5 h / 0 °C 2.1: 66 percent / Jones' reagent / acetone / 1.5 h / 0 °C View Scheme

1: 78 percent / DIBAL-H / toluene / 1.5 h / -78 °C 2: 75 percent / AlMe3, Zn / tetrahydrofuran / 12 h / Ambient temperature View Scheme

1: 2,2-dimethyloxazolidine-(4R)-3,4-dicarboxylic acid 3-tert-butyl ester 4-methyl ester With LiOH*H2O in methanol; water T=20°C; 4 h; Inert atmosphere; 2: O,N-dimethyl-hydroxylamine hydrochloride With (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine in dichloromethane T=20°C; 3 h; Inert atmosphere;

1: water; lithium hydroxide hydrate / methanol / 4 h / 20 °C 2: (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine / 3 h / 20 °C View Scheme

1: 2,2-dimethyloxazolidine-(4R)-3,4-dicarboxylic acid 3-tert-butyl ester 4-methyl ester With diisobutylaluminium hydride in n-heptane; dichloromethane T=-78°C; 2: (1-Diazo-2-oxo-propyl)-phosphonic acid dimethyl ester With potassium carbonate in methanol; n-heptane; dichloromethane T=20°C; Further stages.;

lithium hydroxide in tetrahydrofuran; water 5.66667 h;