2-甲基喹啉-6-羧酸甲酯合成路线 （共 6 条）
反应条件
sulfuric acid 24 h; Heating;
参考文献
Bottino, F. A.; Pasquale, G. Di; Pollicino, A.; Recca, A.; Staniland, P. A.
Journal of Heterocyclic Chemistry, 1989 , vol. 26, p. 929 - 931
反应条件
palladium dichloride in acetonitrile T=80°C; 24 h;
参考文献
Matsubara, Yoshio; Hirakawa, Saori; Yamaguchi, Yoshihiro; Yoshida, Zen-Ichi
Angewandte Chemie - International Edition, 2011 , vol. 50, # 33 p. 7670 - 7673
反应条件
1.1: hydrogenchloride / water / 2 h / |Reflux 1.2: 12.75 h 2.1: sulfuric acid / 12 h / 0 - 65 °C View Scheme
参考文献
Tolmachev, A. A.; Kozlov, E. S.; Slominskii, Yu. L.
J. Gen. Chem. USSR (Engl. Transl.), 1987 , vol. 57, # 1 p. 113 - 117,96 - 99
反应条件
ammonium hydroxide in methanol
T=45°C; 12 h;
参考文献
RHIZEN PHARMACEUTICALS SA; INCOZEN THERAPEUTICS PVT. LTD.; VAKKALANKA, Swaroop Kumar Venkata Satya; NAGARATHNAM, Dhanapalan; VISWANADHA, Srikant; MUTHUPPALANIAPPAN, Meyyappan; BABU, Govindarajulu; BHAVAR, Prashant K
Patent: WO2013/144737 A2, 2013 ;
Location in patent: Paragraph 252 ;
反应条件
1: ammonium hydroxide / methanol / 12 h / 45 °C
2: triethylamine; trifluoroacetic anhydride / chloroform / 1.5 h / 10 °C
View Scheme
参考文献
RHIZEN PHARMACEUTICALS SA; INCOZEN THERAPEUTICS PVT. LTD.; VAKKALANKA, Swaroop Kumar Venkata Satya; NAGARATHNAM, Dhanapalan; VISWANADHA, Srikant; MUTHUPPALANIAPPAN, Meyyappan; BABU, Govindarajulu; BHAVAR, Prashant K
Patent: WO2013/144737 A2, 2013 ;
