6-甲基-3,4-二氢-2H-异喹啉-1-酮合成路线 （共 5 条）
反应条件
phosphorus pentoxide; trichlorophosphate T=110°C; 1 h;
参考文献
NOVARTIS AG; Bock, Mark Gary; Gaul, Christoph; Gummadi, Venkateshwar Rao; Moebitz, Henrik; Sengupta, Saumitra
Patent: US2014/45872 A1, 2014 ;
Location in patent: Paragraph 1035 ;
反应条件
1: triethylamine / N,N-dimethyl-formamide / 1 h / 0 - 25 °C 2: trifluorormethanesulfonic acid / 9 h / 0 - 70 °C View Scheme
参考文献
Kurouchi, Hiroaki; Kawamoto, Kyoko; Sugimoto, Hiromichi; Nakamura, Satoshi; Otani, Yuko; Ohwada, Tomohiko
Journal of Organic Chemistry, 2012 , vol. 77, # 20 p. 9313 - 9328,16
反应条件
1.1: sodium hydroxide / ethanol; water / 2 h / 0 °C 1.2: Cooling with ice 2.1: chloro-trimethyl-silane; lithium borohydride / tetrahydrofuran 3.1: sodium carbonate / chloroform / 0 °C 4.1: trichlorophosphate; phosphorous pentoxide / 1 h / 110 °C 4.2: Cooling with ice View Scheme
参考文献
NOVARTIS AG; Bock, Mark Gary; Gaul, Christoph; Gummadi, Venkateshwar Rao; Moebitz, Henrik; Sengupta, Saumitra
Patent: US2014/45872 A1, 2014 ;
反应条件
1.1: sodium carbonate / chloroform / 0 °C 2.1: trichlorophosphate; phosphorous pentoxide / 1 h / 110 °C 2.2: Cooling with ice View Scheme
参考文献
NOVARTIS AG; Bock, Mark Gary; Gaul, Christoph; Gummadi, Venkateshwar Rao; Moebitz, Henrik; Sengupta, Saumitra
Patent: US2014/45872 A1, 2014 ;
反应条件
1.1: chloro-trimethyl-silane; lithium borohydride / tetrahydrofuran 2.1: sodium carbonate / chloroform / 0 °C 3.1: trichlorophosphate; phosphorous pentoxide / 1 h / 110 °C 3.2: Cooling with ice View Scheme
参考文献
NOVARTIS AG; Bock, Mark Gary; Gaul, Christoph; Gummadi, Venkateshwar Rao; Moebitz, Henrik; Sengupta, Saumitra
Patent: US2014/45872 A1, 2014 ;
