sodium hydroxide; water in ethanol T=60°C; Hydrolysis; 2 h;

1: 89 percent / pyridine / 2 h / 20 °C 2: 77 percent / phenyltrimethylammonium tribromide / tetrahydrofuran / 6 h / 20 °C 3: 73 percent / acetonitrile / 48 h / 20 °C 4: NaH / tetrahydrofuran / Heating 5: 451 mg / H2SO4 / acetic acid / 1.5 h / 60 °C 6: 91 percent / NaOH; H2O / ethanol / 2 h / 60 °C View Scheme

1: 77 percent / phenyltrimethylammonium tribromide / tetrahydrofuran / 6 h / 20 °C 2: 73 percent / acetonitrile / 48 h / 20 °C 3: NaH / tetrahydrofuran / Heating 4: 451 mg / H2SO4 / acetic acid / 1.5 h / 60 °C 5: 91 percent / NaOH; H2O / ethanol / 2 h / 60 °C View Scheme

1: 73 percent / acetonitrile / 48 h / 20 °C 2: NaH / tetrahydrofuran / Heating 3: 451 mg / H2SO4 / acetic acid / 1.5 h / 60 °C 4: 91 percent / NaOH; H2O / ethanol / 2 h / 60 °C View Scheme

1: 451 mg / H2SO4 / acetic acid / 1.5 h / 60 °C 2: 91 percent / NaOH; H2O / ethanol / 2 h / 60 °C View Scheme

1: NaH / tetrahydrofuran / Heating 2: 451 mg / H2SO4 / acetic acid / 1.5 h / 60 °C 3: 91 percent / NaOH; H2O / ethanol / 2 h / 60 °C View Scheme