4-甲氧基-2-硝基苯乙酸乙酯合成路线 （共 4 条）
反应条件
1: acetic acid; iron / 1 h / 100 °C 2: water; hydrogen bromide / 16 h / 120 °C View Scheme
参考文献
ZENOBIA THERAPEUTICS, INC.; BOUNAUD, Pierre-Yves; NIENABER, Vicki; STEENSMA, Ruo, W.; LOWE, John, A., III
Patent: WO2012/178015 A2, 2012 ;
WO 2012/178015 A2
反应条件
iron in acetic acid T=100°C; 1 h;
参考文献
Quallich; Morrissey
Synthesis, 1993 , # 1 p. 51 - 53
反应条件
lithium hydroxide hydrate; water in dimethyl sulfoxide
T=100°C; 2 h;
参考文献
ZENOBIA THERAPEUTICS, INC.; BOUNAUD, Pierre-Yves; NIENABER, Vicki; STEENSMA, Ruo, W.; LOWE, John, A., III
Patent: WO2012/178015 A2, 2012 ;
Location in patent: Page/Page column 130 ;
WO 2012/178015 A2
反应条件
1: 1) NaH / 1) DMSO, 100 deg C, 40 min, 2a) RT, 30 min, 2b) 100 deg C, 1 h
2: 71 percent / LiCl / dimethylsulfoxide; H2O / 3 h / 100 °C
View Scheme
参考文献
Quallich; Morrissey
Synthesis, 1993 , # 1 p. 51 - 53
