4-氨基-5-氯-2-乙氧基苯甲酸合成路线 （共 10 条）
反应条件
sodium hydroxide; water in ethanol 5 h; Heating;
参考文献
Kato; Morie; Kon; Yoshida; Karasawa; Matsumoto
Journal of Medicinal Chemistry, 1991 , vol. 34, # 2 p. 616 - 624
反应条件
1: 98.4 percent / K2CO3 / dimethylformamide / 24 h / 20 - 30 °C 2: NCS / dimethylformamide / 3 h / 70 °C 3: 86.9 percent / 4N NaOH / methanol / 2 h / Heating View Scheme
参考文献
Chemical and Pharmaceutical Bulletin, , vol. 46, # 1 p. 42 - 52
反应条件
1: NCS / dimethylformamide / 3 h / 70 °C 2: 86.9 percent / 4N NaOH / methanol / 2 h / Heating View Scheme
参考文献
Chemical and Pharmaceutical Bulletin, , vol. 46, # 1 p. 42 - 52
反应条件
1: sulfuric acid / 2 h / 20 °C 2: acetic acid / 1 h 3: sodium hydroxide / N,N-dimethyl-formamide 4: N-chloro-succinimide / N,N-dimethyl-formamide 5: sodium hydroxide / ethanol View Scheme
参考文献
Letters in Drug Design and Discovery, , vol. 9, # 5 p. 489 - 493
反应条件
1: acetic acid / 1 h 2: sodium hydroxide / N,N-dimethyl-formamide 3: N-chloro-succinimide / N,N-dimethyl-formamide 4: sodium hydroxide / ethanol View Scheme
参考文献
Letters in Drug Design and Discovery, , vol. 9, # 5 p. 489 - 493
反应条件
1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride in dichloromethane 4 h; Ambient temperature; Yield given;
参考文献
Journal of Medicinal Chemistry, , vol. 34, # 2 p. 616 - 624
反应条件
1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride in dichloromethane 4 h; Ambient temperature; Yield given;
参考文献
Journal of Medicinal Chemistry, , vol. 34, # 2 p. 616 - 624
反应条件
1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride in dichloromethane 4 h; Ambient temperature; Yield given;
参考文献
Kato; Morie; Kon; Yoshida; Karasawa; Matsumoto
Journal of Medicinal Chemistry, 1991 , vol. 34, # 2 p. 616 - 624
反应条件
1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride in dichloromethane 4 h; Ambient temperature; Yield given;
参考文献
Kato; Morie; Kon; Yoshida; Karasawa; Matsumoto
Journal of Medicinal Chemistry, 1991 , vol. 34, # 2 p. 616 - 624
反应条件
1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride in dichloromethane 4 h; Ambient temperature;
参考文献
Journal of Medicinal Chemistry, , vol. 33, # 5 p. 1406 - 1413
