1.1: urea hydrogen peroxide addition compound; phthalic anhydride / ethyl acetate; water / 4 h / 45 °C 2.1: pyridine; trifluoromethanesulfonic anhydride / acetonitrile / 1 h / 70 - 75 °C 2.2: 2 h View Scheme

1.1: urea hydrogen peroxide addition compound; phthalic anhydride / water; ethyl acetate / 45 °C 2.1: trifluoromethanesulfonic anhydride; pyridine / acetonitrile / 1.33 h / 70 - 75 °C 2.2: 2 h / 20 °C 3.1: triethylamine; 4-(N,N-dimethlyamino)pyridine / toluene / 2 h 4.1: hydrogenchloride; water / acetonitrile / 40 - 45 °C View Scheme

1: 2-bromo-3-methyl-pyridine With potassium carbonate in water; toluene T=65°C; 1 h; 2: 3-(tert-butoxycarbonyl)phenylboronic acid With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride in water; toluene T=80°C; 2 h;

potassium carbonate in water; toluene