4-溴-2-三甲基硅烷噻唑合成路线 （共 6 条）
反应条件
1: 2,4-dibromo-1,3-thiazole With n-butyllithium in diethyl ether; hexane T=-78°C; 1.41667 h; 2: chloro-trimethyl-silane in diethyl ether; hexane T=-78°C; 0.333333 h;
参考文献
Wyeth
Patent: US2007/4786 A1, 2007 ;
Location in patent: Page/Page column 21 ;
US 20070004786 A1
反应条件
1: With n-butyllithium in diethyl ether; pentane T=-78°C; 1.5 h; 2: in diethyl ether; pentane T=-78°C; 1.16667 h;
参考文献
VERTEX PHARMACEUTICALS INCORPORATED
Patent: WO2004/87698 A2, 2004 ;
Location in patent: Page 37; 50 ;
WO 2004/087698 A2
反应条件
n-butyllithium 1.) diethyl ether, -78 deg C, 1 h, 2.) -78 deg C, 1 h; Yield given. Multistep reaction;
参考文献
Synthesis, , # 9 p. 757 - 760
反应条件
n-butyllithium 1.) diethyl ether, -78 deg C, 30 min, 2.) diethyl ether, -78 deg C, 1 h; Yield given. Multistep reaction;
参考文献
Journal of Organic Chemistry, , vol. 53, # 8 p. 1748 - 1761
反应条件
Yield given. Multistep reaction. Yields of byproduct given;
参考文献
Dondoni, A.; Mastellari, A. R.; Medici, A.; Negrini, E.; Pedrini, P.
Synthesis, 1986 , # 9 p. 757 - 760
反应条件
n-butyllithium 1.) n-hexane, ether, -78 deg C, 30 min, 2.) -78 deg C, 30 min; Yield given. Multistep reaction;
参考文献
Dondoni, Alessandro; Fantin, Giancarlo; Fogagnolo, Marco; Medici, Alessandro; Pedrini, Paola
Synthesis, 1987 , # 11 p. 998 - 1001
