2-三氟甲基吡啶-4-甲醛合成路线 （共 3 条）
反应条件
phosphoric acid; dimethyl sulfoxide; dicyclohexyl-carbodiimide 1.5 h; Ambient temperature;
参考文献
Ashimori; Ono; Uchida; Ohtaki; Fukaya; Watanabe; Yokoyama
Chemical and Pharmaceutical Bulletin, 1990 , vol. 38, # 9 p. 2446 - 2458
反应条件
1: 2) KMnO4 / 1) Pd(PPh3)4 / 1) dioxane, hexane, reflux, 2) H2O, reflux 2: 1) NEt3, ethyl chloroformate, 2) LiAlH4 / 1) benzene, rt, 1 h, 2) THF, -78 deg C, 30 min 3: 69 percent / DMSO, N,N'-dicyclohexylcarbodiimide, H3PO4 / 1.5 h / Ambient temperature View Scheme
参考文献
Chemical and Pharmaceutical Bulletin, , vol. 38, # 9 p. 2446 - 2458
反应条件
1: 1) NEt3, ethyl chloroformate, 2) LiAlH4 / 1) benzene, rt, 1 h, 2) THF, -78 deg C, 30 min 2: 69 percent / DMSO, N,N'-dicyclohexylcarbodiimide, H3PO4 / 1.5 h / Ambient temperature View Scheme
参考文献
Chemical and Pharmaceutical Bulletin, , vol. 38, # 9 p. 2446 - 2458
