反应条件
Multi-step reaction with 4 steps 1.1: bromine / methanol; acetonitrile / 0 - 5 °C / Large scale reaction2.1: sodium sulfide / N,N-dimethyl-formamide / 0.5 h / 60 °C2.2: 3 h / 60 °C2.3: 60 °C3.1: sodium hydroxide / ethanol / 80 °C / Large scale reaction3.2: Large scale reaction4.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / water; acetonitrile / 1.5 h / 20 °C
参考文献
Patel, Bharti; Firkin, Catherine R.; Snape, Evan W.; Jenkin, Shelley L.; Brown, David; Chaffey, Julian G. K.; Hopes, Philip A.; Reens, Carl D.; Butters, Mike; Moseley, Jonathan D. Organic Process Research and Development, 2012 , vol. 16, # 3 p. 447 - 460
