反应条件
1: benzyl alcohol With potassium tert-butylate in tetrahydrofuran 0.5 h; Reflux; 2: 2,4-Dichloro-pyrimidine in tetrahydrofuran; N,N-dimethyl-formamide T=-78°C; 1 h;
参考文献
VERTEX PHARMACEUTICALS INCORPORATED; WANG, Tiansheng; HANZELKA, Brian; MUH, Ute; BEMIS, Guy; ZUCCOLA, Harmon, J.
Patent: WO2011/19405 A1, 2011 ;
Location in patent: Page/Page column 107 ;
WO 2011/019405 A1
