1-甲基-1H-吲哚-3-羧酸甲酯合成路线 （共 20 条）
反应条件
potassium hydroxide in acetonitrile 1.5 h; Heating;
参考文献
Everett, Steven A.; Naylor, Matthew A.; Stratford, Michael R.L.; Patel, Kantilal B.; Ford, Eleonora; Mortensen, Alan; Ferguson, Amanda C.; Vojnovic, Borivoj; Wardman, Peter
Journal of the Chemical Society, Perkin Transactions 2, 2001 , # 10 p. 1989 - 1997
反应条件
1: 50 percent / CH2Cl2 / 2 h / 80 °C 2: 100 percent / 1N NaOH / methanol / 25 °C View Scheme
参考文献
Nakatsuka, Shin-ichi; Asano, Osamu; Goto, Toshio
Heterocycles, 1986 , vol. 24, # 10 p. 2791 - 2792
反应条件
1: 82 percent / KOH / H2O / 2 h / Heating 2: 1) iPr2NLi / 1) THF, hexane, 0.5 h, -70 deg C, 2) 0.5 h, to r.t. View Scheme
参考文献
Buttery, Cheryl D.; Jones, Richard G.; Knight, David W.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1993 , # 13 p. 1425 - 1432
反应条件
NaH in N,N-dimethyl-formamide; mineral oil
参考文献
Affinium Pharmaceuticals, Inc.
Patent: EP1226138 B1, 2004 ;
反应条件
potassium carbonate in water; N,N-dimethyl-formamide
参考文献
Jiang, Xinglong; Tiwari, Ashish; Thompson, Maethonia; Chen, Zhihong; Cleary, Thomas P.; Lee, Thomas B. K.
Organic Process Research and Development, 2001 , vol. 5, # 6 p. 604 - 608
反应条件
iodine; palladium diacetate; potassium carbonate in N,N-dimethyl-formamide
T=80°C; P=760.051 Torr; 48 h;
参考文献
Lang, Rui; Shi, Lijun; Li, Dengfeng; Xia, Chungu; Li, Fuwei
Organic Letters, 2012 , vol. 14, # 16 p. 4130 - 4133
反应条件
potassium carbonate in acetone
24 h; Heating;
参考文献
Buttery, Cheryl D.; Jones, Richard G.; Knight, David W.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1993 , # 13 p. 1425 - 1432
反应条件
N,N,N',N',N'',N''-hexamethylphosphoric triamide; samarium diiodide in tetrahydrofuran
T=0 - 20°C; Condensation; decyanation; 12 h;
参考文献
Lin, Shu-Chen; Yang, Fwu-Duo; Shiue, Jiann-Shyng; Yang, Shyh-Ming; Fang, Jim-Min
Journal of Organic Chemistry, 1998 , vol. 63, # 9 p. 2909 - 2917
反应条件
copper quinolate in water; dimethyl sulfoxide
T=120°C; 24 h;
参考文献
Zhu, Yan; Yan, Hong; Lu, Linhua; Liu, Defu; Rong, Guangwei; Mao, Jincheng
Journal of Organic Chemistry, 2013 , vol. 78, # 19 p. 9898 - 9905
反应条件
potassium carbonate in N,N-dimethyl-formamide
T=130°C; 5 h; RefluxGreen chemistry;
参考文献
Jiang, Xinglong; Tiwari, Ashish; Thompson, Maethonia; Chen, Zhihong; Cleary, Thomas P.; Lee, Thomas B. K.
Organic Process Research and Development, 2001 , vol. 5, # 6 p. 604 - 608
