N-(2,2-二甲氧基乙基)-4-甲氧基-1,3-苯并二氧戊环-5-甲胺合成路线 （共 4 条）
反应条件
1.1: methanol; water / 1 h / 0 - 20 °C 1.2: 2 h / 0 - 20 °C 2.1: hydrogenchloride / water / 24 h / 20 °C 3.1: sodium tetrahydroborate; trifluoroacetic acid / dichloromethane / 25 h / 0 - 20 °C 4.1: iodine; potassium acetate / ethanol / 3 h / 80 °C View Scheme
参考文献
Mao, Yongjun; Song, Shuai; Zhao, Dongmei; Cheng, Maosheng
Heterocycles, 2013 , vol. 87, # 12 p. 2633 - 2640
反应条件
1.1: methanol; water / 1 h / 0 - 20 °C
1.2: 2 h / 0 - 20 °C
2.1: hydrogenchloride / water / 24 h / 20 °C
3.1: sodium tetrahydroborate; trifluoroacetic acid / dichloromethane / 25 h / 0 - 20 °C
View Scheme
参考文献
Mao, Yongjun; Song, Shuai; Zhao, Dongmei; Cheng, Maosheng
Heterocycles, 2013 , vol. 87, # 12 p. 2633 - 2640
反应条件
hydrogenchloride; hydrogen; palladium on activated charcoal
1)r.t., 4 d, 2) r.t.; Yield given. Multistep reaction;
参考文献
Shirasaka, Tadashi; Takuma, Yuki; Shimpuku, Tetsuro; Imaki, Naoshi
Journal of Organic Chemistry, 1990 , vol. 55, # 12 p. 3767 - 3771
反应条件
With sodium tetrahydroborate in methanol
参考文献
Fleischhacker, Wilhelm; Richter, Bernd; Urban, Ernst Monatshefte fuer Chemie, 1989 , vol. 120, p. 765 - 770
