1-(N-Boc-氨基甲基)-4-(氨基甲基)苯合成路线 （共 11 条）
反应条件
in dichloromethane T=20°C;
参考文献
Ghanem, Mohamed A.; Chretien, Jean-Mathieu; Pinczewska, Aleksandra; Kilburn, Jeremy D.; Bartlett, Philip N.
Journal of Materials Chemistry, 2008 , vol. 18, # 41 p. 4917 - 4927
反应条件
sodium hydroxide in 1,4-dioxane; water T=20°C; Cooling with ice;
参考文献
Keller, Max; Erdmann, Daniela; Pop, Nathalie; Pluym, Nikola; Teng, Shangjun; Bernhardt, Guenther; Buschauer, Armin
Bioorganic and Medicinal Chemistry, 2011 , vol. 19, # 9 p. 2859 - 2878
反应条件
triethylamine in tetrahydrofuran; dichloromethane; water
参考文献
Glaxo Wellcome Inc.
Patent: US6090846 A1, 2000 ;
反应条件
1: With lithium aluminium tetrahydride in tetrahydrofuran T=0 - 20°C; 49 h; Inert atmosphere; 2: With water; sodium hydroxide T=0°C; 0.25 h; Inert atmosphere;
参考文献
Mok, N. Yi; Chadwick, James; Kellett, Katherine A. B.; Casas-Arce, Eva; Hooper, Nigel M.; Johnson, A. Peter; Fishwick, Colin W. G.
Journal of Medicinal Chemistry, 2013 , vol. 56, # 5 p. 1843 - 1852
反应条件
in ethanol T=80°C; Reflux;
参考文献
US2013/281515 A1, ;
Paragraph 0178; 0179 ;
反应条件
1: H2 / 5 percent Pd/C / tetrahydrofuran / 2 h / 20 °C / 2327.17 Torr 2: tetrahydrofuran / 2 h / 20 °C 3: NaBH4; aq. CoCl2 / tetrahydrofuran / 24 h / 35 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 13, # 20 p. 3477 - 3482
反应条件
1: aq. NaN3 / tetrahydrofuran / 18 h / 20 °C 2: H2 / 5 percent Pd/C / tetrahydrofuran / 2 h / 20 °C / 2327.17 Torr 3: tetrahydrofuran / 2 h / 20 °C 4: NaBH4; aq. CoCl2 / tetrahydrofuran / 24 h / 35 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 13, # 20 p. 3477 - 3482
反应条件
1: tetrahydrofuran / 2 h / 20 °C 2: NaBH4; aq. CoCl2 / tetrahydrofuran / 24 h / 35 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 13, # 20 p. 3477 - 3482
反应条件
1.1: triethylamine / dichloromethane / 16 h / 0 - 20 °C / |Inert atmosphere 2.1: lithium aluminium tetrahydride / tetrahydrofuran / 49 h / 0 - 20 °C / |Inert atmosphere 2.2: 0.25 h / 0 °C / |Inert atmosphere View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 56, # 5 p. 1843 - 1852
反应条件
1.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 1 h / 60 °C 2.1: thionyl chloride / methanol / 0 - 20 °C 3.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 20 - 90 °C 4.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 0 °C 4.2: 18 h / 95 °C View Scheme
参考文献
Zhu, Aizhi; Zhan, Weiqiang; Liang, Zhongxing; Yoon, Younghyoun; Yang, Hua; Grossniklaus, Hans E.; Xu, Jianguo; Rojas, Mauricio; Lockwood, Mark; Snyder, James P.; Liotta, Dennis C.; Shim, Hyunsuk
Journal of Medicinal Chemistry, 2010 , vol. 53, # 24 p. 8556 - 8568
