5-溴-2,3-二氢苯并[B]呋喃-7-羰基氯合成路线 （共 5 条）
反应条件
thionyl chloride; N,N-dimethyl-formamide in chloroform 2 h; Heating;
参考文献
Hogberg; De Paulis; Johansson; Kumar; Hall; Ogren
Journal of Medicinal Chemistry, 1990 , vol. 33, # 8 p. 2305 - 2309
反应条件
1: 79 percent / sodium acetate, bromine / acetic acid / 3 h / 80 °C 2: dimethylformamide, thionyl chloride / toluene / 1 h / 65 °C View Scheme
参考文献
Hogberg; De Paulis; Johansson; Kumar; Hall; Ogren
Journal of Medicinal Chemistry, 1990 , vol. 33, # 8 p. 2305 - 2309
反应条件
1: Br2 / acetic acid / Ambient temperature 2: 1.) n-BuLi / 1.) THF, hexane, -78 deg C, 2.) -78 deg C 3: SOCl2, N,N-dimethylformamide / CHCl3 / 2 h / Heating View Scheme
参考文献
Murphy; Kung; Billings
Journal of Medicinal Chemistry, 1990 , vol. 33, # 1 p. 171 - 178
反应条件
1: 1.) n-BuLi / 1.) THF, hexane, -78 deg C, 2.) -78 deg C 2: SOCl2, N,N-dimethylformamide / CHCl3 / 2 h / Heating View Scheme
参考文献
Murphy; Kung; Billings
Journal of Medicinal Chemistry, 1990 , vol. 33, # 1 p. 171 - 178
反应条件
1: CHCl3 / 2 h / Ambient temperature 2: 1.) hexabutylditin, palladium(II) acetate, tetrakis(triphenylphosphine)palladium(0), triethylamine, 2.) I2 / 1.) 85 deg C, 2.5 h, 2.) CH3Cl, RT View Scheme
参考文献
Murphy; Kung; Billings
Journal of Medicinal Chemistry, 1990 , vol. 33, # 1 p. 171 - 178
